Aryloxy substituted N-arylpiperazinones as dual inhibitors of farnesyltransferase and geranylgeranyltransferase-I.
作者信息
Bergman J M, Abrams M T, Davide J P, Greenberg I B, Robinson R G, Buser C A, Huber H E, Koblan K S, Kohl N E, Lobell R B, Graham S L, Hartman G D, Williams T M, Dinsmore C J
机构信息
Department of Medicinal Chemistry, Merck Research Laboratories, West Point, PA 19486, USA.
出版信息
Bioorg Med Chem Lett. 2001 Jun 4;11(11):1411-5. doi: 10.1016/s0960-894x(01)00240-2.
Abstract
A series of aryloxy substituted piperazinones with dual farnesyltransferase/geranylgeranyltransferase-I inhibitory activity was prepared. These compounds were found to have potent inhibitory activity in vitro and are promising agents for the inhibition of Ki-Ras signaling.
摘要
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