Potent, non-thiol inhibitors of farnesyltransferase.

作者信息

Breslin M J, deSolms S J, Giuliani E A, Stokker G E, Graham S L, Pompliano D L, Mosser S D, Hamilton K A, Hutchinson J H

机构信息

Department of Medicinal Chemistry, Merck Research Laboratories, West Point, PA 19486, USA.

出版信息

Bioorg Med Chem Lett. 1998 Dec 1;8(23):3311-6. doi: 10.1016/s0960-894x(98)00586-1.

DOI:10.1016/s0960-894x(98)00586-1

PMID:9873725

Abstract

The structure-activity relationship of a series of non-thiol CaaX analogs, which are inhibitors of farnesyltransferase, is described. These inhibitors contain a substituted phenyl group at the N terminus, which may occupy a novel binding domain on the Ras protein.

摘要