Fastbom J
Neurotec, Karolinska institutet och Stockholms läns äldrecentrum.
Lakartidningen. 2001 Apr 4;98(14):1674-9.
With aging comes an increasing prevalence of diseases and symptoms that frequently require pharmaceutical treatment. However, aging also brings about bodily changes that result in increased effects and prolonged action of many drugs. Multiple drug use--often termed polypharmacy--seen in many elderly individuals, is the most important risk factor for adverse drug reactions (ADR) and increases the risk of drug interactions and poor compliance. ADR's are responsible for about 10% of all hospital admissions of elderly patients. The drugs most commonly involved are cardiovascular, psychotropics and anti-inflammatory agents. Many of these ADR's are dose-dependent and preventable. Drug use has increased over the last few years, largely thanks to the availability of new and effective agents. This calls for increased vigilance and prudence in prescribing for the elderly.
随着年龄的增长,疾病和症状的患病率不断上升,常常需要药物治疗。然而,衰老也会带来身体变化,导致许多药物的作用增强和作用时间延长。在许多老年人中常见的多种药物使用——通常称为多药合用——是药物不良反应(ADR)的最重要风险因素,会增加药物相互作用和依从性差的风险。药物不良反应约占老年患者住院总数的10%。最常涉及的药物是心血管药物、精神药物和抗炎药。这些药物不良反应中的许多是剂量依赖性的且可预防。在过去几年中,药物使用有所增加,这在很大程度上要归功于新型有效药物的可得性。这就要求在为老年人开处方时提高警惕并谨慎行事。