Blekinge Centre of Competence, SE-371 81, Karlskrona, Sweden.
BMC Public Health. 2012 Jul 31;12:575. doi: 10.1186/1471-2458-12-575.
There is a great variability in licit prescription drug use in the population and among patients. Factors other than purely medical ones have proven to be of importance for the prescribing of licit drugs. For example, individuals with a high age, female gender and low socioeconomic status are more likely to use licit prescription drugs. However, these results have not been adjusted for multi-morbidity level. In this study we investigate the odds of using licit prescription drugs among individuals in the population and the rate of licit prescription drug use among patients depending on gender, age and socioeconomic status after adjustment for multi-morbidity level.
The study was carried out on the total population aged 20 years or older in Östergötland county with about 400 000 inhabitants in year 2006. The Johns Hopkins ACG Case-mix was used as a proxy for the individual level of multi-morbidity in the population to which we have related the odds ratio for individuals and incidence rate ratio (IRR) for patients of using licit prescription drugs, defined daily doses (DDDs) and total costs of licit prescription drugs after adjusting for age, gender and socioeconomic factors (educational and income level).
After adjustment for multi-morbidity level male individuals had less than half the odds of using licit prescription drugs (OR 0.41 (95% CI 0.40-0.42)) compared to female individuals. Among the patients, males had higher total costs (IRR 1.14 (95% CI 1.13-1.15)). Individuals above 80 years had nine times the odds of using licit prescription drugs (OR 9.09 (95% CI 8.33-10.00)) despite adjustment for multi-morbidity. Patients in the highest education and income level had the lowest DDDs (IRR 0.78 (95% CI 0.76-0.80), IRR 0.73 (95% CI 0.71-0.74)) after adjustment for multi-morbidity level.
This paper shows that there is a great variability in licit prescription drug use associated with gender, age and socioeconomic status, which is not dependent on level of multi-morbidity.
人口中以及患者之间的合法处方药物使用存在很大的差异。除了纯粹的医学因素外,其他因素已被证明对合法药物的处方有重要影响。例如,年龄较大、女性和社会经济地位较低的个体更有可能使用合法处方药物。然而,这些结果并未根据多病共存水平进行调整。在这项研究中,我们调查了人群中个体使用合法处方药物的几率以及患者中合法处方药物使用的比率,具体取决于性别、年龄和社会经济地位,同时调整了多病共存水平。
该研究在 2006 年针对人口中年龄在 20 岁或以上的总人口进行,该人群约有 40 万居民。使用约翰霍普金斯 ACG 病例组合作为人群中个体多病共存水平的替代指标,我们将其与个体使用合法处方药物、定义日剂量(DDD)和合法处方药物总费用的比值相关联,这些药物的使用比率经过年龄、性别和社会经济因素(教育和收入水平)的调整。
在调整多病共存水平后,与女性个体相比,男性个体使用合法处方药物的几率不到一半(比值比 0.41(95%置信区间 0.40-0.42))。在患者中,男性的总费用更高(相对危险比 1.14(95%置信区间 1.13-1.15))。尽管调整了多病共存水平,80 岁以上的个体使用合法处方药物的几率增加了九倍(比值比 9.09(95%置信区间 8.33-10.00))。在调整了多病共存水平后,处于最高教育和收入水平的患者的 DDDs 最低(相对危险比 0.78(95%置信区间 0.76-0.80),相对危险比 0.73(95%置信区间 0.71-0.74))。
本文表明,合法处方药物的使用存在很大的差异,与性别、年龄和社会经济地位有关,而与多病共存水平无关。