Larson B, Bremme K, Clyne N, Nordström L
Departments of Obstetrics and Gynaecology and Nephrology, Karolinska Hospital, Stockholm, and Roche AB, Stockholm, Sweden.
Acta Obstet Gynecol Scand. 2001 Jun;80(6):559-62.
To compare the effects of preoperative treatment with recombinant human erythropoietin (EPO) and iron with iron only on hemoglobin levels (Hb) in anemic women prior to hysterectomy.
The study was an open-labelled randomized parallel study. Fifteen women scheduled for hysterectomy due to uterine myoma were given oral iron and EPO (NeoRecormon) 4 weeks prior to surgery (group I) and 16 women were given oral iron only (group II).
Group I showed a significantly greater increase in mean Hb during the pre-surgery study period compared with group II (p=0.007). Two weeks postoperatively, however, there was no significant difference in mean Hb between the two groups.
We found that a significantly greater increase in Hb was achieved with iron in combination with EPO, although in most cases iron only seemed to be as efficacious as iron+EPO in correcting anemia in myoma patients pre-operatively.
比较术前使用重组人促红细胞生成素（EPO）和铁剂联合治疗与单纯使用铁剂对子宫切除术前贫血女性血红蛋白水平（Hb）的影响。
本研究为开放标签随机平行研究。15例因子宫肌瘤计划行子宫切除术的女性在术前4周给予口服铁剂和EPO（促红细胞生成素）（第一组），16例女性仅给予口服铁剂（第二组）。
与第二组相比，第一组在术前研究期间平均Hb的升高显著更大（p = 0.007）。然而，术后两周，两组之间的平均Hb无显著差异。
我们发现铁剂联合EPO可使Hb显著升高，尽管在大多数情况下，单纯铁剂在术前纠正肌瘤患者贫血方面似乎与铁剂+EPO同样有效。
