Larsen T K, Friis S, Haahr U, Joa I, Johannessen J O, Melle I, Opjordsmoen S, Simonsen E, Vaglum P
University of Oslo, Norway, Roskilde County Psychiatric Hospital Fjorden, Denmark, Rogaland Psychiatric Hospital, Norway, Ullevål Hospital, Oslo, Norway.
Acta Psychiatr Scand. 2001 May;103(5):323-34. doi: 10.1034/j.1600-0447.2001.00131.x.
To review the literature on early intervention in psychosis and to evaluate relevant studies.
Early intervention was defined as intervention in the prodromal phase (primary prevention) and intervention after the onset of psychosis, i.e. shortening of duration of untreated psychosis (DUP) (secondary prevention).
We found few studies aimed at early intervention, but many papers discussing the idea at a more general level. We identified no studies that prove that intervention in the prodromal phase is possible without a high risk for treating false positives. We identified some studies aimed at reducing DUP, but the results are ambiguous and, until now, no follow-up data showing a positive effect on prognosis have been presented.
Early intervention in psychosis is a difficult and important challenge for the psychiatric health services. At the time being reduction of DUP seems to be the most promising strategy. Intervention in the prodromal phase is more ethically and conceptually problematic.
回顾关于精神病早期干预的文献并评估相关研究。
早期干预被定义为在前驱期的干预（一级预防）以及精神病发作后的干预，即缩短未治疗精神病持续时间（DUP）（二级预防）。
我们发现针对早期干预的研究较少，但有许多论文在更普遍层面讨论了这一理念。我们未发现有研究能证明在前驱期进行干预且无高假阳性治疗风险是可行的。我们确定了一些旨在缩短DUP的研究，但其结果不明确，且目前尚未有显示对预后有积极影响的随访数据。
精神病的早期干预对精神卫生服务而言是一项困难且重要的挑战。目前，缩短DUP似乎是最有前景的策略。在前驱期进行干预在伦理和概念上存在更多问题。
