Dykes A C, Walker I D, McMahon A D, Islam S I, Tait R C
Department of Haematology, Glasgow Royal Infirmary, Scotland, UK.
Br J Haematol. 2001 Jun;113(3):636-41. doi: 10.1046/j.1365-2141.2001.02813.x.
Total Protein S (tPS) and free Protein S (fPS) antigen levels were measured in 3788 healthy blood donors. Men had higher levels of both parameters than women (P < 0.001). Age had no effect on tPS in men, although there was a slight reduction in fPS levels with increasing age. In women increasing age was associated with a significant increase in tPS levels (P < 0.001) but had no effect on fPS after adjustment for menopausal state. Oral contraceptive pill (OCP) use significantly lowered tPS but had no effect on fPS. In post-menopausal women, hormone replacement therapy (HRT) use had no statistically significant effect on either tPS or fPS. Donors with tPS or fPS levels in the lowest percentile (n = 56) were retested; only nine with repeat low levels were identified, eight of whom had persistently low levels over a 4-7-year follow-up. Acquired deficiency was excluded. When possible, family studies were performed, leading to an estimate of prevalence of familial PS deficiency of between 0.03% and 0.13% in the general population.
对3788名健康献血者检测了总蛋白S（tPS）和游离蛋白S（fPS）抗原水平。男性的这两项指标水平均高于女性（P<0.001）。年龄对男性的tPS无影响，不过随着年龄增长fPS水平略有降低。在女性中，年龄增长与tPS水平显著升高相关（P<0.001），但在调整绝经状态后对fPS无影响。口服避孕药（OCP）的使用显著降低了tPS，但对fPS无影响。在绝经后女性中，激素替代疗法（HRT）的使用对tPS或fPS均无统计学显著影响。对tPS或fPS水平处于最低百分位数的献血者（n=56）进行了重新检测；仅9人重复检测结果仍较低，其中8人在4至7年的随访中持续处于低水平。排除了获得性缺乏。尽可能进行了家族研究，由此估计普通人群中家族性蛋白S缺乏的患病率在0.03%至0.13%之间。
