一项关于新生儿失配负波的研究。
A study of mismatch negativity in newborns.
作者信息
Tanaka M, Okubo O, Fuchigami T, Harada K
机构信息
Departments of Pediatrics, Nihon University School of Medicine, Tokyo, Japan.
出版信息
Pediatr Int. 2001 Jun;43(3):281-6. doi: 10.1046/j.1442-200x.2001.01395.x.
BACKGROUND
Although newborns are presumed to have cognitive ability, studies on the objective cognitive ability of neonates are making little progress.
METHODS
We gave auditory and visual stimuli to newborns whose conceptional age ranged from 35 to 43 weeks and recorded the mismatch negativity (MMN) that is said to reflect the process by which stimuli are detected automatically. We compared the waveform and latency of the MMN.
RESULTS
The mismatch negativity waveform in newborns was similar to that of adults. The MMN latency tended to shorten with an advance in conceptional age and was especially shortened between 36 and 37 weeks of fetal life. In some newborns whose clinical course indicated a possibility of their having cognitive dysfunction, the MMN latency was prolonged.
CONCLUSIONS
Newborns also have cognitive ability and MMN is useful for objectively evaluating the cognitive ability in newborns.
背景
尽管新生儿被认为具有认知能力，但关于新生儿客观认知能力的研究进展甚微。
方法
我们对孕龄在35至43周的新生儿给予听觉和视觉刺激，并记录据说能反映刺激自动检测过程的失匹配负波（MMN）。我们比较了MMN的波形和潜伏期。
结果
新生儿的失匹配负波波形与成人相似。MMN潜伏期往往随着孕龄的增加而缩短，在胎儿期36至37周时尤其缩短。在一些临床病程显示可能存在认知功能障碍的新生儿中，MMN潜伏期延长。
结论
新生儿也具有认知能力，MMN有助于客观评估新生儿的认知能力。
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