Davis J L, Cherkin A
Psychopharmacology (Berl). 1979 Jun 21;63(3):269-72. doi: 10.1007/BF00433560.
Three experiments describe retroactive memory enhancement in chicks by chlorpromazine (CPZ), a potent membrane stabilizer at anesthetic doses. First, chicks trained on a one-trial peck suppression task under moderate aversant conditions and given 60--144 mg CPZ/kg, intraperitoneally, displayed increased memory retention 24 h later when compared with chicks given saline or 15--36 mg CPZ/kg. The second experiment confirmed the memory enhancement using a different moderate aversant on a different peck target and extended the effect to 48 h. The third experiment demonstrated the CPZ effect to be retrograde because the enhancement observed when CPZ was injected 1 min or 3 min after training did not occur when injection was delayed 4 h. One speculative interpretation of retrograde enhancement with CPZ includes the stabilization of swollen dendritic spines, which may facilitate neuronal pathways.
三项实验描述了氯丙嗪（CPZ）对雏鸡的记忆回溯增强作用，氯丙嗪是一种在麻醉剂量下具有强大膜稳定作用的药物。首先，在中等厌恶条件下接受单次啄击抑制任务训练的雏鸡，腹腔注射60 - 144毫克/千克的CPZ，与注射生理盐水或15 - 36毫克/千克CPZ的雏鸡相比，24小时后显示出记忆保持能力增强。第二个实验使用不同的中等厌恶刺激和不同的啄击目标证实了记忆增强作用，并将这种效果延长至48小时。第三个实验证明CPZ的作用是逆行性的，因为在训练后1分钟或3分钟注射CPZ时观察到的增强作用，在注射延迟4小时时并未出现。对CPZ逆行性增强作用的一种推测性解释包括肿胀树突棘的稳定，这可能有助于神经元通路。
