Woolverton W L, Balster R L
Psychopharmacology (Berl). 1979 Jun 28;64(1):19-24. doi: 10.1007/BF00427339.
The effects of phencyclidine (PCP) on the behavior of rats responding to a fixed-interval 1 min schedule of water delivery were determined before, during, and after a period of daily PCP injections. The effects of acute PCP on overall response rate were biphasic: low doses increased and high doses decreased rates. In addition, PCP produced a dose-related decrease in quarter-life and high doses of PCP decreased the number of reinforcers delivered. During the daily injection regimen roughly a two-fold tolerance developed to the effects of 8.0 mg/kg PCP on response rate in animals receiving either presession or post-session injections of this dose, emphasizing the predominance of pharmacological variables in PCP tolerance. However, slight differences between these groups in tolerance development and in the rate of tolerance loss demonstrate that behavioral variables can influence tolerance to the behavioral effects of PCP.
在每日注射苯环己哌啶（PCP）一段时间之前、期间和之后，测定了PCP对按固定间隔1分钟送水时间表做出反应的大鼠行为的影响。急性PCP对总体反应率的影响是双相的：低剂量增加反应率，高剂量降低反应率。此外，PCP导致四分位数寿命呈剂量相关下降，高剂量PCP减少了给予的强化物数量。在每日注射方案期间，接受会前或会后注射该剂量的动物对8.0mg/kg PCP对反应率的影响大致产生了两倍的耐受性，这强调了药理学变量在PCP耐受性中的主导地位。然而，这些组在耐受性发展和耐受性丧失速率方面的细微差异表明，行为变量可以影响对PCP行为效应的耐受性。
