Jortani S A, Willetts J, Balster R L
Department of Pharmacology and Toxicology, Medical College of Virginia, Virginia Commonwealth University, Richmond 23298-0613.
Neurosci Lett. 1992 Jan 20;135(1):136-8. doi: 10.1016/0304-3940(92)90154-y.
Systemic administration of magnesium chloride was evaluated for phencyclidine (PCP)-like discriminative stimulus effects. Six rats were trained to discriminate PCP (1.25 mg/kg, i.p.) from saline under a two-lever fixed-ratio 32 schedule of food reinforcement. Magnesium chloride (10-80 mg/kg, i.p.) failed to substitute for PCP, with no dose producing greater than an average of 21% PCP-lever responding. At doses greater than 40 mg/kg, magnesium chloride decreased rates of responding, providing evidence that it was evaluated over a behaviorally-relevant dose range. The results provide further evidence for differences in the behavioral effects of drugs which antagonize N-methyl-D-aspartate receptor-mediated neurotransmission by different mechanisms.
对氯化镁进行全身给药以评估其类似苯环利定（PCP）的辨别刺激效应。六只大鼠在两杆固定比率32的食物强化程序下接受训练，以区分PCP（1.25毫克/千克，腹腔注射）和生理盐水。氯化镁（10 - 80毫克/千克，腹腔注射）未能替代PCP，没有任何剂量产生的PCP杆反应大于平均21%。在大于40毫克/千克的剂量下，氯化镁降低了反应速率，这表明它是在行为相关的剂量范围内进行评估的。这些结果为通过不同机制拮抗N - 甲基 - D - 天冬氨酸受体介导的神经传递的药物在行为效应上的差异提供了进一步的证据。
