Gillette E L, Maurer G D, Severin G A
Radiology. 1975 Jul;116(1):175-7. doi: 10.1148/116.1.175.
Lamellar keratectomy was performed in dogs to induce capillary endothelial proliferation at the limbus of the eye and the radiation response of endothelial cells was evaluated in terms of the dose required to prevent neovascularization in 50% of irradiated eyes (NVD50).Single- and split-dose experiments were carried out before and after induction of proliferation to determine the response of slowly and rapidly proliferating endothelial cells. the NVD-50-S prior to induction were about 400 rads greater than those following induction,indicating increased resistance of slowly proliferating cells. Split-dose studies indicatedthat the radiation repair capability was about 350 rads, either before or after induction.
在犬类动物中进行板层角膜切除术以诱导眼缘处的毛细血管内皮细胞增殖，并根据防止50%受照射眼睛出现新生血管所需的剂量（NVD50）来评估内皮细胞的辐射反应。在诱导增殖前后分别进行了单剂量和分割剂量实验，以确定缓慢增殖和快速增殖的内皮细胞的反应。诱导前的NVD-50-S比诱导后的大约高400拉德，表明缓慢增殖细胞的抗性增加。分割剂量研究表明，诱导前后的辐射修复能力约为350拉德。
