用快中子对微脉管系统进行辐照。
Irradiation of the microvasculature with fast neutrons.
作者信息
Fike J R, Gillette E L, Edwards F M, Kraushaar J J, Prull D E
出版信息
Radiology. 1979 Jun;131(3):763-6. doi: 10.1148/131.3.763.
Single- and split-dose irradiation of the eyes of dogs was performed with cyclotron-produced polyenergetic neutrons at a rate of about 0.2 Gy (20 rad) per minute. Neovascularization was subsequently induced surgically in the avascular corneas and stimulated for 7 days to study the response of slowly proliferating capillary endothelial cells. Corneal tissue samples were evaluated quantitatively by morphometric methods. A dose-response curve was drawn by plotting per cent capillary volume versus dose. D0 was 2 Gy (200 rad), and the recovery ability was determined to be equivalent to 1.3 Gy (130 rad). Depending on the level of damage, relative biological effectiveness (RBE) values were 1.9 to 2.3.
用回旋加速器产生的多能中子以每分钟约0.2戈瑞（20拉德）的剂量率对狗的眼睛进行单剂量和分剂量照射。随后通过手术在无血管的角膜中诱导新生血管形成，并刺激7天，以研究缓慢增殖的毛细血管内皮细胞的反应。通过形态测量方法对角膜组织样本进行定量评估。通过绘制毛细血管体积百分比与剂量的关系绘制剂量反应曲线。D0为2戈瑞（200拉德），恢复能力确定相当于1.3戈瑞（130拉德）。根据损伤程度，相对生物效应（RBE）值为1.9至2.3。
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