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钌红和N-乙基马来酰胺对人红细胞锂外流的影响。

The effect of ruthenium red and NEM on lithium efflux from human erythrocytes.

作者信息

Meltzer H L

出版信息

Psychopharmacology (Berl). 1979 Jun 28;64(1):25-30. doi: 10.1007/BF00427340.

DOI:10.1007/BF00427340
PMID:113827
Abstract

The lithium pump in intact human erythrocytes which has previously been shown to be repressed following lithium carbonate ingestion by manic-depressive subjects is now shown to be inhibited selectively by N-ethylmaleimide and ruthenium red, both of which are known to inhibit the erythrocyte Ca pump. It is proposed that active lithium efflux is linked to the concurrent operation of the calcium pump.

摘要

完整人类红细胞中的锂泵,此前已表明在躁郁症患者摄入碳酸锂后会受到抑制,现在发现它会被N - 乙基马来酰亚胺和钌红选择性抑制,这两种物质都已知会抑制红细胞钙泵。有人提出,活性锂外流与钙泵的同时运作有关。

相似文献

1
The effect of ruthenium red and NEM on lithium efflux from human erythrocytes.钌红和N-乙基马来酰胺对人红细胞锂外流的影响。
Psychopharmacology (Berl). 1979 Jun 28;64(1):25-30. doi: 10.1007/BF00427340.
2
Lithium efflux through the Na/K pump in human erythrocytes.锂通过人类红细胞中的钠钾泵流出。
Proc Natl Acad Sci U S A. 1977 Jul;74(7):3099-103. doi: 10.1073/pnas.74.7.3099.
3
Ruthenium red-insensitive Ca2+ uptake and release by mitochondria.钌红不敏感的线粒体钙摄取与释放
Arch Biochem Biophys. 1985 Nov 15;243(1):70-9. doi: 10.1016/0003-9861(85)90774-x.
4
Locus of N-ethylmaleimide action on sugar transport in nucleated erythrocytes.N-乙基马来酰亚胺对有核红细胞糖转运作用的位点
Am J Physiol. 1981 Jul;241(1):C33-41. doi: 10.1152/ajpcell.1981.241.1.C33.
5
N-ethylmaleimide discriminates between two lysine transport systems in human erythrocytes.N-乙基马来酰亚胺可区分人类红细胞中的两种赖氨酸转运系统。
J Physiol. 1993 Aug;468:753-66. doi: 10.1113/jphysiol.1993.sp019799.
6
Active efflux of lithium from erythrocytes of manic-depressive subjects.躁郁症患者红细胞中锂的主动外排。
Life Sci. 1976 Aug 1;19(3):371-9. doi: 10.1016/0024-3205(76)90041-2.
7
Stable enhancement of ruthenium red-insensitive calcium transport in an endoplasmic reticulum-rich fraction following the exposure of isolated rat liver cells to glucagon.
FEBS Lett. 1979 Aug 1;104(1):31-4. doi: 10.1016/0014-5793(79)81079-0.
8
Activation by N-ethylmaleimide of a latent K+-Cl- flux in human red blood cells.N-乙基马来酰亚胺对人红细胞中潜在钾氯通量的激活作用。
Am J Physiol. 1984 May;246(5 Pt 1):C385-90. doi: 10.1152/ajpcell.1984.246.5.C385.
9
Submitochondrial location of ruthenium red-sensitive calcium-ion transport and evidence for its enrichment in a specific population of rat liver mitochondria.钌红敏感的钙离子转运在线粒体中的定位及其在大鼠肝脏特定线粒体群体中富集的证据。
Biochem J. 1978 Sep 15;174(3):1011-9. doi: 10.1042/bj1741011.
10
Role of 3',5'-cyclic AMP in glucagon-induced stimulation of ruthenium red-insensitive calcium transport in an endoplasmic reticulum-rich fraction of rat liver.3',5'-环磷酸腺苷在胰高血糖素诱导的大鼠肝脏富含内质网部分中钌红不敏感钙转运刺激作用中的角色
FEBS Lett. 1980 Mar 24;112(1):92-6. doi: 10.1016/0014-5793(80)80136-0.

本文引用的文献

1
Calcium efflux from human erythrocyte ghosts.人红细胞胞影中钙的外流。
J Membr Biol. 1970 Dec;2(1):324-40. doi: 10.1007/BF01869868.
2
Effects of sulfhydryl inhibition on red blood cells. I. Mechanism of hemolysis.巯基抑制对红细胞的影响。I. 溶血机制。
J Clin Invest. 1962 Apr;41(4):779-92. doi: 10.1172/JCI104536.
3
Adenosinetriphosphatase activity and the active movements of alkali metal ions.三磷酸腺苷酶活性与碱金属离子的主动转运
J Physiol. 1961 Apr;156(2):274-93. doi: 10.1113/jphysiol.1961.sp006675.
4
ATP-dependent Ca++-extrusion from human red cells.人红细胞中依赖三磷酸腺苷的钙离子排出
Experientia. 1966 Jun 15;22(6):364-5. doi: 10.1007/BF01901136.
5
Active uptake of Ca++ and Ca plus,plus-activated Mg++ ATPase in red cell membrane fragments.红细胞膜片段中钙离子的主动摄取以及钙激活的镁离子ATP酶
J Gen Physiol. 1971 Feb;57(2):202-15. doi: 10.1085/jgp.57.2.202.
6
Studies on the active transport of calcium in human red cells.人体红细胞中钙的主动运输研究。
J Gen Physiol. 1969 Dec;54(6):713-29. doi: 10.1085/jgp.54.6.713.
7
The control by internal calcium of membrane permeability to sodium and potassium.膜对钠和钾的通透性的内部钙调控。
J Physiol. 1971 May;214(3):481-507. doi: 10.1113/jphysiol.1971.sp009445.
8
Red blood cell calcium and magnesium: effects upon sodium and potassium transport and cellular morphology.红细胞钙和镁:对钠和钾转运及细胞形态的影响。
Biochim Biophys Acta. 1974 May 30;352(1):97-116. doi: 10.1016/0005-2736(74)90182-5.
9
Active calcium and strontium transport in human erythrocyte ghosts.人体红细胞膜囊泡中钙和锶的主动转运
J Gen Physiol. 1969 Mar;53(3):311-22. doi: 10.1085/jgp.53.3.311.
10
Electrophoretic separation of different phophosproteins associated with Ca-ATPase and Na, K-ATPase in human red cell ghosts.人红细胞膜中与钙 -ATP 酶和钠钾 -ATP 酶相关的不同磷蛋白的电泳分离
J Gen Physiol. 1974 Mar;63(3):324-36. doi: 10.1085/jgp.63.3.324.