钌红和N-乙基马来酰胺对人红细胞锂外流的影响。

The effect of ruthenium red and NEM on lithium efflux from human erythrocytes.

作者信息

Meltzer H L

出版信息

Psychopharmacology (Berl). 1979 Jun 28;64(1):25-30. doi: 10.1007/BF00427340.

Abstract

The lithium pump in intact human erythrocytes which has previously been shown to be repressed following lithium carbonate ingestion by manic-depressive subjects is now shown to be inhibited selectively by N-ethylmaleimide and ruthenium red, both of which are known to inhibit the erythrocyte Ca pump. It is proposed that active lithium efflux is linked to the concurrent operation of the calcium pump.

摘要

完整人类红细胞中的锂泵，此前已表明在躁郁症患者摄入碳酸锂后会受到抑制，现在发现它会被N - 乙基马来酰亚胺和钌红选择性抑制，这两种物质都已知会抑制红细胞钙泵。有人提出，活性锂外流与钙泵的同时运作有关。