Burgener F A, Fischer H W
Radiology. 1975 Jul;116(1):49-52. doi: 10.1148/116.1.49.
C-terminal octapeptide of cholecystokinin was administered at six dose levels, 4-128 ng/kg, by 184 intravenous injections to three mongrel dogs under several pressure conditions of the biliary system. Gallbladder contraction was monitored radiographically. A good, dose-dependent contraction response resulted with intraductal pressures of 0 and 10 cm water. At 20 cm water, a markedly reduced and dose-independent response occurred. No contraction response was found with an intraductal pressure of 30 cm water. This animal experimental work suggests that in man, a contraction response of 30% or more may rule out significant common bile duct obstruction.
在胆道系统的几种压力条件下，通过184次静脉注射，以4 - 128 ng/kg的六个剂量水平给三只杂种狗施用胆囊收缩素的C末端八肽。通过X射线摄影监测胆囊收缩情况。在胆管内压力为0和10厘米水柱时，产生了良好的剂量依赖性收缩反应。在20厘米水柱时，反应明显减弱且与剂量无关。在胆管内压力为30厘米水柱时未发现收缩反应。这项动物实验工作表明，在人类中，30%或更高的收缩反应可能排除胆总管的明显梗阻。
