Kokkinidis L, Anisman H
Psychopharmacology (Berl). 1979 Jun 28;64(1):45-54. doi: 10.1007/BF00427344.
Systemic treatment with d-amphetamine produced a dose-dependent increase in the circling behavior of normal mice. Treatment with both alpha-methyl-p-tyrosine (alpha-MpT) and FLA-63 antagonized the amphetamine-induced circling behavior. Similarly, blockade of B-adrenergic receptors by propranolol and dopamine receptors by haloperidol reversed the circling response elicited by amphetamine. In contrast to alpha-MpT and haloperidol, however, neither FLA-63 nor propranolol attenuated the locomotor excitation engendered by amphetamine. Following repeated d-amphetamine injections the circling ordinarily induced by a single injection was abolished, whereas the locomotor effects of amphetamine remained unaltered. These findings are consistent with earlier work suggesting that tolerance may occur in those behaviors that involve a noradrenergic component.
用右旋苯丙胺进行全身治疗可使正常小鼠的转圈行为呈剂量依赖性增加。用α-甲基对酪氨酸（α-MpT）和FLA-63治疗均能拮抗苯丙胺诱导的转圈行为。同样，普萘洛尔对β-肾上腺素能受体的阻断以及氟哌啶醇对多巴胺受体的阻断可逆转苯丙胺引起的转圈反应。然而，与α-MpT和氟哌啶醇不同的是，FLA-63和普萘洛尔均未减弱苯丙胺引起的运动兴奋。重复注射右旋苯丙胺后，单次注射通常诱导的转圈行为消失，而苯丙胺的运动效应保持不变。这些发现与早期的研究结果一致，表明在那些涉及去甲肾上腺素能成分的行为中可能会出现耐受性。
