Cheng H C, Bhatnagar R K, Long J P
Eur J Pharmacol. 1975 Sep-Oct;33(2):319-24. doi: 10.1016/0014-2999(75)90176-4.
d-Amphetamine was found to induce a pecking response in pigeons. The pecking response induced by d-amphetamine was antagonized by chlorpromazine, haloperidol or bulbocapnine indicating that this pecking response was caused by dopaminergic receptor stimulation. Pretreatment of pigeons with alpha-methyltyrosine (alpha-MT) reduced d-amphetamine-induced pecking, while the combined treatment of pigeons with alpha-MT and L-dihydroxyphenylalanine (L-DOPA, 100 mg/kg) partially restored the pecking response. d-Amphetamine-induced pecking was not reduced by a dopamine-beta-hydroxylase inhibitor, 1-phenyl-3-(2-thiazolyl)-2-thiourea (U-14,624). Alpha-MT reduced brain dopamine but not norepinephrine level, whereas U-14,624 decreased brain norepinephrine but not dopamine. Thus there is a correlation between brain dopamine level and d-amphetamine-induced pecking response. It is concluded that d-amphetamine-induced pecking is mediated indirectly by the release of dopamine.
发现右旋苯丙胺可诱导鸽子产生啄食反应。氯丙嗪、氟哌啶醇或荷包牡丹碱可拮抗右旋苯丙胺诱导的啄食反应，这表明这种啄食反应是由多巴胺能受体刺激引起的。用α-甲基酪氨酸（α-MT）预处理鸽子可减少右旋苯丙胺诱导的啄食，而将鸽子用α-MT和左旋二羟基苯丙氨酸（L-DOPA，100mg/kg）联合处理可部分恢复啄食反应。多巴胺-β-羟化酶抑制剂1-苯基-3-（2-噻唑基）-2-硫脲（U-14,624）不会降低右旋苯丙胺诱导的啄食。α-MT降低了脑内多巴胺水平，但未降低去甲肾上腺素水平，而U-14,624降低了脑内去甲肾上腺素水平，但未降低多巴胺水平。因此，脑内多巴胺水平与右旋苯丙胺诱导的啄食反应之间存在相关性。得出的结论是，右旋苯丙胺诱导的啄食是由多巴胺释放间接介导的。
