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肋软骨移植在髁突切除术后颞下颌关节重建中的应用:一项在绵羊身上的实验研究

Costochondral grafts in reconstruction of the temporomandibular joint after condylectomy: an experimental study in sheep.

作者信息

Matsuura H, Miyamoto H, Ishimaru J I, Kurita K, Goss A N

机构信息

Oral and Maxillofacial Surgery Unit, Dental School, The University of Adelaide, Adelaide, South Australia.

出版信息

Br J Oral Maxillofac Surg. 2001 Jun;39(3):189-95. doi: 10.1054/bjom.2001.0622.

DOI:10.1054/bjom.2001.0622
PMID:11384115
Abstract

The purpose of this study was to investigate the effect of costochondral grafts in the temporomandibular joint (TMJ) in sheep. Five pure-bred adult Merino sheep were used. The condyle alone was resected and replaced with a costochondral graft from the 13th rib. The sheep were killed 3 months after operation. The range of jaw movements before and after operation and at death were recorded. The joints were examined radiologically, macroscopically, and histologically. A new condylar head with normal configuration and function developed. Histologically, the chondrocytes were arranged in a fashion similar to that of a normal joint. All inferior joint spaces showed fibrous adhesions between the condylar head and disc. This study showed that, when such grafts are used to replace the condyle in an otherwise normal sheep TMJ, they fused to the ramus and reconstituted a nearly normal, fully functional joint.

摘要

本研究的目的是调查肋软骨移植对绵羊颞下颌关节(TMJ)的影响。使用了5只纯种成年美利奴绵羊。仅切除髁突,并用第13肋的肋软骨移植进行替换。术后3个月处死绵羊。记录手术前后及处死时的下颌运动范围。对关节进行放射学、宏观和组织学检查。形成了具有正常形态和功能的新髁突头。组织学上,软骨细胞的排列方式与正常关节相似。所有下颌关节间隙均显示髁突头与关节盘之间存在纤维粘连。本研究表明,当使用此类移植来替换原本正常的绵羊颞下颌关节中的髁突时,它们与下颌支融合并重建了一个几乎正常、功能完全的关节。

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引用本文的文献

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Morphologic and histologic characterization of sheep and porcine TMJ as large animal models for tissue engineering applications.以绵羊和猪的 TMJ 为大动物模型进行组织工程应用的形态学和组织学特征。
Clin Oral Investig. 2022 Jul;26(7):5019-5027. doi: 10.1007/s00784-022-04472-3. Epub 2022 Apr 1.
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Evaluation of the Sternoclavicular Graft for the Reconstruction of Temporomandibular Joint After Gap Arthroplasty.胸锁关节移植用于颞下颌关节间隙成形术后重建的评估
Ann Maxillofac Surg. 2017 Jul-Dec;7(2):194-201. doi: 10.4103/ams.ams_120_16.
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Preclinical Animal Models for Temporomandibular Joint Tissue Engineering.
颞下颌关节组织工程的临床前动物模型。
Tissue Eng Part B Rev. 2018 Jun;24(3):171-178. doi: 10.1089/ten.TEB.2017.0341. Epub 2018 Jan 2.
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Fate of Costochondral Graft in Temporomandibular Joint Reconstruction: A Histological Study.颞下颌关节重建中肋软骨移植物的转归:一项组织学研究
J Maxillofac Oral Surg. 2016 Jun;15(2):179-83. doi: 10.1007/s12663-015-0823-0. Epub 2015 Jul 26.