James B O, Wells D M, Grant L S
Trop Geogr Med. 1975 Mar;27(1):39-46.
The enteric flora of a group of antibiotic-treated patients and two groups of non-antibiotic-treated individuals were studied for antibiotic resistance patterns and presence of transferable R-factors. The former group consisted of 100 hospitalised patients, the latter two groups consisted of 200 hospitalised patients and 200 individuals from rural communities in Jamaica. The occurrence of multiple-resistant organisms with transferable R-factors was significantly higher in the antibiotic-treated group. R-factors were also more common in the hospitalised, non-treated group than in the non-hospitalised, non-treated group. Follow-up studies on hospitalised patients showed a tendency to increased occurrence of R-factors with duration of hospitalisation, whether the patients were treated with antibiotics or not. These studies have shown that both antibiotic treatment and hospitalisation promote the occurrence of R-factors.
对一组接受抗生素治疗的患者以及两组未接受抗生素治疗的个体的肠道菌群进行了研究，以了解抗生素耐药模式和可转移R因子的存在情况。前一组由100名住院患者组成，后两组分别由200名住院患者和200名来自牙买加农村社区的个体组成。在接受抗生素治疗的组中，带有可转移R因子的多重耐药菌的发生率显著更高。R因子在住院的未治疗组中也比在未住院的未治疗组中更常见。对住院患者的随访研究表明，无论患者是否接受抗生素治疗，随着住院时间的延长，R因子的发生率都有增加的趋势。这些研究表明，抗生素治疗和住院都会促进R因子的出现。
