一名患有副肿瘤性视网膜病变和结肠癌患者的视网膜抗双极细胞抗体
Retinal anti-bipolar cell antibodies in a patient with paraneoplastic retinopathy and colon carcinoma.
作者信息
Jacobson D M, Adamus G
机构信息
Department of Neurology, Marshfield Clinic, Marshfield, Wisconsin 54449, USA.
出版信息
Am J Ophthalmol. 2001 Jun;131(6):806-8. doi: 10.1016/s0002-9394(00)00925-9.
PURPOSE
To describe clinical, electrophysiologic, and immunologic features of a unique paraneoplastic retinopathy with characteristics of cancer-associated and melanoma-associated retinopathy.
METHODS
Serial assessment of clinical visual function, electroretinography, and assays of anti-retinal antibodies.
RESULTS
A 51-year-old woman with progressive visual glare for 1 year had normal visual acuity and color vision, paracentral scotomas, and a normal-appearing retina. Electroretinography revealed no responses of the right eye and attenuated responses of the left eye, especially those recorded under scotopic conditions. Anti-bipolar antibodies were detected. Subsequent evaluation uncovered adenocarcinoma of the colon. Several months after resection of the tumor and chemotherapy, no evidence existed of cancer or anti-bipolar cell antibodies, and electroretinography responses were markedly improved.
CONCLUSION
The presence of anti-bipolar cell antibodies in a patient with retinal dysfunction is not specific of melanoma-associated retinopathy. Effective treatment of cancer may result in elimination of associated anti-retinal antibodies and improved retinal function.
目的
描述一种具有癌症相关性视网膜病变和黑色素瘤相关性视网膜病变特征的独特副肿瘤性视网膜病变的临床、电生理和免疫学特征。
方法
对临床视觉功能、视网膜电图进行系列评估，并检测抗视网膜抗体。
结果
一名51岁女性，渐进性视觉眩光1年，视力和色觉正常，有旁中心暗点，视网膜外观正常。视网膜电图显示右眼无反应，左眼反应减弱，尤其是在暗视条件下记录的反应。检测到抗双极细胞抗体。随后的评估发现患有结肠腺癌。肿瘤切除和化疗数月后，没有癌症或抗双极细胞抗体的证据，视网膜电图反应明显改善。
结论
视网膜功能障碍患者中存在抗双极细胞抗体并非黑色素瘤相关性视网膜病变所特有。有效治疗癌症可能会导致相关抗视网膜抗体的消除和视网膜功能的改善。
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