Hauw J, Berger B, Escourolle R
Acta Neuropathol. 1975;31(3):229-42. doi: 10.1007/BF00684562.
The ulstrastructural characteristics of the cerebellum and olfactory bulb capillaries were studied in 12 human specimen measuring 25-200 mm. Type I capillaries, whose lumina were wider than 8 mu, contained no pores of fenestrations. The basement membrane was sometimes discontinous. In that case, junctions without quintuple-layered zones could be observed. Such capillaries may correspond to primary vessels in which the sinusoid character has disappeared. Elsewhere, the basement membrane was continuous and the interendothelial junctions always contained quintuple-layered zones. Type II capillaries, whose lumina measured between 2 and 8 mu had basement membranes that were either discontinuous or continuous. They were identical to the immature capillaries described previously in numerous species including man. Type III caillaries, rarely observed, were characterized by the presence of several endothelial cells with abundant cytoplasm, which limited the mina from 0.5 --3 mu in diameters. They had continuous basement membranes. Type IV and V capillaries has small or non-patent lumina. The basement membrane was absent or rudimentary. These capillaries appeared to correspond to simple and complexendothelial sprouts. In Types II, III, V and most Type IV capillaries, the interendothelial junctions contained quintuple-layered zones. No mature capillaries were observed. The hypothetical pathways of development of cerebral capillaries and the degree of permeability of immature interendothelial junctions are discussed. The long duration of maturation in man probably accounts for the diversity of capillary formations observed as compared with animals. The co-existence over along period of time of several capillary types with probably varying permeability may play a significant role in the maturation of the blood-brain barrier.
对12例25 - 200毫米的人体标本的小脑和嗅球毛细血管的超微结构特征进行了研究。I型毛细血管，其管腔宽度大于8微米，没有窗孔。基底膜有时不连续。在这种情况下，可以观察到没有五层区的连接。这种毛细血管可能对应于窦状特征消失的初级血管。在其他地方，基底膜是连续的，内皮细胞间连接总是包含五层区。II型毛细血管，其管腔直径在2至8微米之间，基底膜要么不连续要么连续。它们与先前在包括人类在内的许多物种中描述的未成熟毛细血管相同。III型毛细血管很少观察到，其特征是有几个内皮细胞，细胞质丰富，将管腔直径限制在0.5 - 3微米。它们有连续的基底膜。IV型和V型毛细血管管腔小或无开放管腔。基底膜不存在或不完整。这些毛细血管似乎对应于简单和复杂的内皮芽。在II型、III型、V型和大多数IV型毛细血管中，内皮细胞间连接包含五层区。未观察到成熟毛细血管。讨论了脑毛细血管发育的假设途径以及未成熟内皮细胞间连接的通透性程度。与动物相比，人类成熟时间长可能是观察到毛细血管形成多样性的原因。几种可能具有不同通透性的毛细血管类型长期共存可能在血脑屏障成熟中起重要作用。
