Pollack I P, Rossi H
Arch Ophthalmol. 1975 Mar;93(3):173-7. doi: 10.1001/archopht.1975.01010020181002.
Norepinephrine (4%) as free base produced a significant fall in intraocular pressure and resistance to outflow. This effect was sustained for up to 20 weeks. No significant difference could be shown between the effect of 2%, 3%, and 4% norepinephrine on the aquious humor dynamics. The effect on pressure and facility was shown in eyes with ocular hypertension and with glaucoma. An additive effect was observed after use of norepinephrine with pilocarpine in the treatment of glaucoma. Crossover studies between epinephrine borate 1% and norepinephrine borate 4% revealed no significant difference. Like epinephrine, norepinephrine produces a conjunctival hyperemia in many patients. However, there is an absence of tachycardia after use of norepinephrine, and one person in this study showed an allergic reaction to epinephrine that cleared promptly and completely when norepinephrine was substituted.
4%的去甲肾上腺素游离碱可使眼压显著下降，并降低房水流出阻力。这种作用可持续长达20周。2%、3%和4%的去甲肾上腺素对房水动力学的影响无显著差异。在高眼压和青光眼眼中均观察到了对眼压和房水流畅系数的影响。在青光眼治疗中，去甲肾上腺素与毛果芸香碱联合使用后观察到了相加作用。1%硼酸肾上腺素和4%硼酸去甲肾上腺素的交叉研究显示无显著差异。与肾上腺素一样，去甲肾上腺素在许多患者中会引起结膜充血。然而，使用去甲肾上腺素后不会出现心动过速，本研究中有一人对肾上腺素过敏，当改用去甲肾上腺素后过敏反应迅速且完全消退。
