Phillips C I, Gore S M, Macdonald M J, Cullen P M
Br J Ophthalmol. 1977 May;61(5):349-53. doi: 10.1136/bjo.61.5.349.
Guttae atenolol 4% (Tenormin), a pure beta1-blocking (i.e., cardioselective) drug, produced a median overall fall of 5-6 mmHg (range 3-2 to 13-2 mmHg) in the first tonometrised eyes of 7 patients with open-angle glaucoma or ocular hypertension and 1 with closed-angle glaucoma (off any treatment for the whole of the day preceding each test day) after allowance for an 'effect' of guttae saline 0-9%, in a double-masked, cross-over trial. By a Wilcoxon matched pairs rank test this was significant at the P less than 0-05 level. The median overall fall of 3-5 mmHg (range 0-8 to 10-8 mmHg) in the second-tonometrised eyes of 7 patients (1 of the 8 contributed only 1 eye) was also significant (P less than 0-05). In 2 patients who had been treated with guttae atenolol 4% daily 3 X for 1 and 2 months there is evidence that, on replacing the atenolol 4% with saline 0-9%, a rise of pressure of around 3 mmHg occurred 2 and 3 and 5 days later, i.e., the drug still retained its effectivity (slightly reduced) after 1 and 2 months.
4%阿替洛尔滴眼液（天诺敏）是一种纯β1受体阻滞剂（即心脏选择性药物），在一项双盲交叉试验中，对7例开角型青光眼或高眼压症患者及1例闭角型青光眼患者（在每个测试日前一整天均未接受任何治疗）的首次眼压测量眼，在考虑0.9%生理盐水“效应”后，眼压中位数总体下降了5 - 6 mmHg（范围为3.2至13.2 mmHg）。通过威尔科克森配对秩和检验，这在P值小于0.05水平时具有显著性。7例患者（8例中的1例仅提供了1只眼）第二次眼压测量眼的眼压中位数总体下降了3.5 mmHg（范围为0.8至10.8 mmHg），这也具有显著性（P值小于0.05）。在2例每天使用3次4%阿替洛尔滴眼液分别达1个月和2个月的患者中，有证据表明，在用0.9%生理盐水替代4%阿替洛尔后，2天、3天和5天后眼压升高了约3 mmHg，即该药物在1个月和2个月后仍保留其有效性（略有降低）。
