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髋部骨折住院6个月后的死亡率和活动能力:风险因素及风险调整后的医院结局

Mortality and locomotion 6 months after hospitalization for hip fracture: risk factors and risk-adjusted hospital outcomes.

作者信息

Hannan E L, Magaziner J, Wang J J, Eastwood E A, Silberzweig S B, Gilbert M, Morrison R S, McLaughlin M A, Orosz G M, Siu A L

机构信息

Department of Health Policy, Management, and Behavior, University at Albany-State University of New York, One University Place, Rensselaer, NY 12144-3456, USA.

出版信息

JAMA. 2001 Jun 6;285(21):2736-42. doi: 10.1001/jama.285.21.2736.

Abstract

CONTEXT

Hip fracture is a common clinical problem that leads to considerable mortality and disability. A need exists for a practical means to monitor and improve outcomes, including function, for patients with hip fracture.

OBJECTIVES

To identify and compare the importance of significant prefracture predictors of functional status and mortality at 6 months for patients hospitalized with hip fracture and to compare risk-adjusted outcomes for hospitals providing initial care.

DESIGN

Prospective study with data obtained from medical records and through structured interviews with patients and proxies.

SETTING AND PARTICIPANTS

A total of 571 adults aged 50 years or older with hip fracture who were admitted to 4 New York, NY, metropolitan hospitals between August 1997 and August 1998.

MAIN OUTCOME MEASURES

In-hospital and 6-month mortality; locomotion at 6 months; and adverse outcomes at 6 months, defined as death or needing assistance to ambulate, compared by hospital, adjusting for patient risk factors.

RESULTS

The in-hospital mortality rate was 1.6%. At 6 months, the mortality rate was 13.5%, and another 12.8% needed total assistance to ambulate. Laboratory values were strong predictors of mortality but were not significantly associated with locomotion. Age and prefracture residence at a nursing home were significant predictors of locomotion (P =.02 for both) but were not significantly associated with mortality. Adjustment for baseline characteristics either substantially augmented or diminished interhospital differences in outcomes. Two hospitals had 1 outcome (functional status or mortality) that was significantly worse than the overall mean while the other outcome was nonsignificantly better than average.

CONCLUSIONS

Mortality and functional status ideally should be considered both together and individually to distinguish effects limited to one or the other outcome. Hospital performance for these 2 measures may differ substantially after adjustment, probably because different processes of care are important to each outcome.

摘要

背景

髋部骨折是一个常见的临床问题,会导致相当高的死亡率和残疾率。对于髋部骨折患者,需要一种实用的方法来监测并改善其包括功能在内的治疗结果。

目的

识别并比较髋部骨折住院患者骨折前显著的功能状态和6个月死亡率预测因素的重要性,并比较提供初始治疗的医院经风险调整后的治疗结果。

设计

前瞻性研究,数据通过病历以及对患者及其代理人的结构化访谈获取。

地点和参与者

1997年8月至1998年8月期间,纽约市4家大都市医院收治的571名50岁及以上的髋部骨折成年患者。

主要观察指标

住院期间及6个月时的死亡率;6个月时的活动能力;6个月时的不良结局,定义为死亡或行走需要协助,按医院进行比较,并对患者风险因素进行调整。

结果

住院死亡率为1.6%。6个月时,死亡率为13.5%,另有12.8%的患者行走需要完全协助。实验室检查值是死亡率的强预测因素,但与活动能力无显著关联。年龄和骨折前居住在养老院是活动能力的显著预测因素(两者P值均为0.02),但与死亡率无显著关联。对基线特征进行调整后,要么显著扩大要么缩小了医院间结局的差异。两家医院的一项结局(功能状态或死亡率)显著差于总体均值,而另一项结局则略好于平均水平但无统计学意义。

结论

理想情况下,应同时综合及分别考虑死亡率和功能状态,以区分仅限于其中一种或另一种结局的影响。调整后,这两项指标的医院表现可能存在很大差异,这可能是因为不同的护理过程对每种结局都很重要。

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