Komajda M, Bouhour J B, Amouyel P, Delahaye F, Vicaut E, Croce I, Rougemond E, Vuittenez F, Leutenegger E
Service de cardiologie, hôpital La Pitié-La Salpêtrière, 47-83, bd de l'Hôpital, 75013 Paris.
Arch Mal Coeur Vaiss. 2001 Apr;94(4):257-61.
An enquiry was undertaken amongst 71 cardiologists in 1999 evaluating 600 ambulatory patients with cardiac failure (64% men; mean age 73 years; NYHA Class I: 9%, Class II: 52%, Class III: 33%, Class IV: 6%). Cardiac failure is commoner in men (81%) before the age of 70. After the age of 80, the tendency is inversed (53% of women). Fifty-two per cent of patients had a history of hospital admission for cardiac failure: 26% in the year before the enquiry (on average 13.1 days' hospital stay). On inclusion, the diagnosis was made 4.2 +/- 4.6 years previously and the patients had been followed up for an average of 3.04 +/- 3.3 years. The diagnosis of cardiac failure was made by the cardiologist (57%), the general practitioner (37%), or another category of physician (6%). Eight per cent of patients were treated with a single drug before inclusion, 22% had a bi-therapy and 70% a polytherapy. The most frequently prescribed drugs were: diuretics (71%), angiotensin converting enzyme (ACE) inhibitors (54%) and digitalis (35%). The prescription of betablockers was only reported in 14% of the population. In the over-80's, only 45% of patients were prescribed ACE inhibitors. These results confirm that ambulatory patients with cardiac failure are mainly in NYHA Classes II and III, that the pathology concerns elderly patients and that it is the cause of recurrent hospital admission. The prescription of diuretics is the main therapy in all NYHA Classes. ACE inhibitors were only prescribed in 2/3 of patients and in less than half of patients over 80 years of age. The prescription of betablockers remains marginal. The reason for the underprescription of recommended drugs (International Recommendations) would justify further investigation.
1999年,对71位心脏病专家进行了一项调查,评估了600例门诊心力衰竭患者(男性占64%;平均年龄73岁;纽约心脏协会心功能分级:I级占9%,II级占52%,III级占33%,IV级占6%)。70岁之前,男性心力衰竭患者更为常见(81%)。80岁之后,这种趋势则相反(女性占53%)。52%的患者有因心力衰竭住院的病史:调查前一年有26%(平均住院13.1天)。纳入研究时,心力衰竭诊断时间为4.2±4.6年前,患者平均随访了3.04±3.3年。心力衰竭诊断由心脏病专家做出的占57%,全科医生做出的占37%,其他类别的医生做出的占6%。纳入研究前,8%的患者接受单一药物治疗,22%接受双联治疗,70%接受三联或更多药物治疗。最常开具的药物为:利尿剂(71%)、血管紧张素转换酶(ACE)抑制剂(54%)和洋地黄(35%)。仅14%的患者使用了β受体阻滞剂。在80岁以上患者中,仅45%的患者使用了ACE抑制剂。这些结果证实,门诊心力衰竭患者主要为纽约心脏协会心功能II级和III级,该疾病多见于老年患者,且是反复住院的原因。利尿剂的使用是所有纽约心脏协会心功能分级中的主要治疗方法。ACE抑制剂仅在2/3的患者中使用,80岁以上患者中使用不到一半。β受体阻滞剂的使用仍然很少。推荐药物(国际推荐)处方不足的原因值得进一步研究。