Rywik Tomasz M, Rywik Stefan L, Korewicki Jerzy, Broda Grazyna, Sarnecka Aleksandra, Drewla Joanna
Heart Failure Department, Stefan Cardinal Wyszyński National Institute of Cardiology, 04-628 Warsaw, Alpejska 42, Poland.
Int J Cardiol. 2004 Jun;95(2-3):177-84. doi: 10.1016/j.ijcard.2003.04.027.
Despite the fact that heart failure constitutes a major health problem there are only limited data regarding pharmacotherapy along with characterization and prognosis of heart failure in the community.
The aim of this study was to investigate treatment pattern in ambulatory patients with heart failure.
The study is a cross-country epidemiological survey, based on registration, by 417 participating physicians, 50 consecutive ambulatory patients aged >/=65 years seeking medical care for any cause.
From a total of 19,877 individuals, 10,579 patients (3901 men and 6678 women, 53% of total) were diagnosed with HF. Therapy with angiotensin converting enzyme inhibitors was recommended in 68%, long acting nitrates in 62%, diuretics in 55%, cardiac glycosides in 31%, Ca blockers in 29% and beta blockers in 22% of all individuals with HF. The prevalence of particular groups of drugs administered in both genders was similar with the exception for calcium blockers, which were more frequently used in women (p<0.001), whereas long acting nitrates in men (p<0.001). In general, angiotensin converting enzyme inhibitors, long acting nitrates and cardiac glycosides use increased with age. On the contrary, beta blockers and calcium blockers were given mostly to younger patients. The most sick patients were more likely to receive angiotensin converting enzyme inhibitors, cardiac glycosides, long acting nitrates and diuretics, whereas less frequently beta blockers and calcium blockers. Combination therapy was used relatively rarely, with lowest percentage in NYHA IV.
Compared to the other population studies, both angiotensin converting enzyme inhibitors and beta blockers were used relatively more frequently, although in the absolute terms the latter was clearly underused. The high rate of Ca blockers prescription is a matter of concern. More attention should be paid to optimising combination usage and introducing beta blockers early in all stable patients.
尽管心力衰竭是一个重大的健康问题,但关于社区心力衰竭的药物治疗以及特征和预后的数据有限。
本研究旨在调查门诊心力衰竭患者的治疗模式。
该研究是一项跨国流行病学调查,基于417名参与医生的登记数据,纳入50名连续就诊的65岁及以上因任何原因寻求医疗护理的门诊患者。
在总共19877名个体中,10579名患者(3901名男性和6678名女性,占总数的53%)被诊断为心力衰竭。在所有心力衰竭患者中,68%的患者被推荐使用血管紧张素转换酶抑制剂,62%的患者使用长效硝酸盐,55%的患者使用利尿剂,31%的患者使用强心苷,29%的患者使用钙通道阻滞剂,22%的患者使用β受体阻滞剂。除钙通道阻滞剂外,两性使用特定药物组的患病率相似,钙通道阻滞剂在女性中使用更频繁(p<0.001),而长效硝酸盐在男性中使用更频繁(p<0.001)。一般来说,血管紧张素转换酶抑制剂、长效硝酸盐和强心苷的使用随年龄增加。相反,β受体阻滞剂和钙通道阻滞剂大多给予年轻患者。病情最严重的患者更有可能接受血管紧张素转换酶抑制剂、强心苷、长效硝酸盐和利尿剂,而接受β受体阻滞剂和钙通道阻滞剂的频率较低。联合治疗相对较少使用,在纽约心脏病协会IV级患者中比例最低。
与其他人群研究相比,血管紧张素转换酶抑制剂和β受体阻滞剂的使用相对更频繁,尽管从绝对数量来看,后者明显使用不足。钙通道阻滞剂的高处方率令人担忧。应更加关注优化联合用药,并在所有稳定患者中尽早引入β受体阻滞剂。