Jondeau G, Allaert F A, Leurs I
Service de cardiologie, Hôpital Ambroise Paré, Faculté de médecine Paris-Ile-de-France Quest, Université Versailles, Saint-Quentin.
Arch Mal Coeur Vaiss. 2004 Sep;97(9):833-9.
The PRINCEPS study (Prise en charge des Insuffisants Cardiaques: Enquête chez les Patients Symptomatiques) was carried out by 1,717 general practitioners who reported their experience with 3,782 patients with cardiac failure treated by an angiotensin converting enzyme (ACE) inhibitor. This is the largest observational study carried out in general practice in France to date. The average age of the patients with cardiac failure was 71 years, with a majority of men (62%), many of whom were hypertensive (76%) and had other cardiovascular risk factors. The diagnosis of cardiac failure was made by the presence of effort dyspnoea (92%) and confirmed by a cardiologist in 81% of cases. Heart failure was rarely chronic (17%>5 years), usually related to hypertension (58%) and had required hospital admission in only 39% of patients. Finally, the patients were not very symptomatic (63% Class II of the NYHA Classification). Treatment included the obligatory ACE inhibitor at a high dosage (maximal dosage according the European Recommendations) in half the patients. The dosage prescribed was considered optimal in 3 out of 4 patients, and usually treated by the consulting cardiologist (81% of patients). It was higher in the young patients, less symptomatic, and in patients with heart failure due to hypertension. A treatment with betablockers (20%), diuretics (74%), digitalis (21%), was often associated with the ACE inhibitor. These results suggest that heart failure patients treated by general practitioners have hypertension as the main cause. The ACE inhibitors seem to be prescribed initially at high dosage for treating the hypertension, and the dosage is progressively decreased with time and aggravation of the cardiac failure.
PRINCEPS研究(心力衰竭患者治疗:有症状患者调查)由1717名全科医生开展,他们报告了对3782例接受血管紧张素转换酶(ACE)抑制剂治疗的心力衰竭患者的治疗经验。这是法国迄今在全科医疗中开展的最大规模观察性研究。心力衰竭患者的平均年龄为71岁,男性占大多数(62%),其中许多人患有高血压(76%)并有其他心血管危险因素。心力衰竭的诊断依据为劳力性呼吸困难(92%),81%的病例经心脏病专家确诊。心力衰竭很少为慢性(病程>5年者占17%),通常与高血压有关(58%),仅39%的患者需要住院治疗。最后,患者症状不太明显(纽约心脏协会分级II级者占63%)。半数患者接受了高剂量(根据欧洲指南的最大剂量)的强制性ACE抑制剂治疗。四分之三患者的处方剂量被认为是最佳的,且通常由会诊心脏病专家治疗(81%的患者)。年轻患者、症状较轻的患者以及因高血压导致心力衰竭的患者剂量更高。ACE抑制剂治疗常联合使用β受体阻滞剂(20%)、利尿剂(74%)、洋地黄(21%)。这些结果表明,全科医生治疗的心力衰竭患者以高血压为主要病因。ACE抑制剂似乎最初以高剂量用于治疗高血压,随着时间推移和心力衰竭加重,剂量逐渐降低。