Shimizu N, Kuwahara Y
Division of Applied Life Sciences, Graduate School of Agriculture, Kyoto University, Japan.
Biosci Biotechnol Biochem. 2001 Apr;65(4):990-2. doi: 10.1271/bbb.65.990.
A new salicyl lactone was detected from the unidentified Oulenzia sp. and its chemical structure was elucidated as 7-hydroxyphthalide (7-hydroxy-3H-isobenzofuran-1-one), based on its GC/MS and GC/FT-IR data and SiO2 column behavior. The compound was synthesized by NaBH4 reduction of 3-hydroxyphthalic anhydride. The GC/MS and GC/FT-IR spectra of the natural compound were consistent with those of the synthetic product. Although the compound is known as a medical material, this is the first example of its presence in nature.
