Mackey J, Treem W R, Worley G, Boney A, Hart P, Kishnani P S
Department of Pediatrics, Duke University Medical Center, Durham, North Carolina 27710, USA.
Clin Pediatr (Phila). 2001 May;40(5):249-52. doi: 10.1177/000992280104000502.
Ninety-three individuals with Down syndrome (DS) were screened to investigate the prevalence of celiac disease (CD) in the United States. Five of the 93 individuals were antiendomysial antibody (EMA) positive. Of the 5 who tested positive for EMA, 4 were biopsied, 1 refused biopsy. Three of the 4 individuals biopsied manifested changes of CD on small bowel biopsy. This gives a frequency of 3.2% of confirmed CD in our DS individuals and suggests the need for periodic screening for celiac disease in this population.
对93名唐氏综合征（DS）患者进行了筛查，以调查美国乳糜泻（CD）的患病率。93名患者中有5名抗肌内膜抗体（EMA）呈阳性。在EMA检测呈阳性的5人中，4人接受了活检，1人拒绝活检。接受活检的4人中，有3人在小肠活检中表现出乳糜泻的变化。这表明我们的唐氏综合征患者中确诊乳糜泻的发生率为3.2%，提示该人群需要定期进行乳糜泻筛查。
