Division of Pediatric Gastroenterology Hepatology and Nutrition, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.
J Trop Pediatr. 2011 Feb;57(1):45-50. doi: 10.1093/tropej/fmq041. Epub 2010 Jun 16.
Serological screening enables us to detect patients of celiac disease (CD) before they develop serious complications. This study was planned to assess the prevalence of CD in the family members of index cases by serological screening.
A prospective study was conducted on 50 children diagnosed to be having CD. Serological screening of the family members of index cases was done and those showing positivity for the screening tests were further subjected to endoscopic duodenal biopsy for histopathological examination.
A total of 164 members of 50 celiac families were initially screened for antibodies. Antibody picked up 32.9% by IgG anti-gliadin (AGA), 20.7% by endomysial antibody, 19.5% by tissue transglutaminase and 14.6% IgA AGA as seropositive for CD. Endoscopic findings characteristics for CD were present in only eight family members.
Family members of CD cases represent potential cases of CD.
血清学筛查使我们能够在患者出现严重并发症之前发现乳糜泻（CD）患者。本研究旨在通过血清学筛查评估指标病例的家庭成员中 CD 的患病率。
对 50 例确诊为 CD 的儿童进行了前瞻性研究。对指标病例的家庭成员进行了血清学筛查，对筛查试验阳性者进一步进行内镜十二指肠活检进行组织病理学检查。
共有 50 个乳糜泻家庭的 164 名成员最初接受了抗体筛查。IgG 抗麦胶蛋白（AGA）检测出 32.9%、肌内膜抗体检测出 20.7%、组织转谷氨酰胺酶检测出 19.5%、IgA AGA 检测出 14.6%的抗体阳性，提示 CD。仅 8 名家庭成员出现 CD 的内镜表现特征。
CD 病例的家庭成员代表潜在的 CD 病例。
