寻找数量性状的分子基础：成功与陷阱

Finding the molecular basis of quantitative traits: successes and pitfalls.

作者信息

Flint J, Mott R

机构信息

Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK.

出版信息

Nat Rev Genet. 2001 Jun;2(6):437-45. doi: 10.1038/35076585.

DOI:10.1038/35076585

PMID:11389460

Abstract

Understanding the molecular basis of quantitative genetic variation is a principal goal for biomedicine. Although the complex genetic architecture of quantitative traits has so far largely frustrated attempts to identify genes in humans by standard linkage methodologies, quantitative trait loci (QTL) have been mapped in plants, insects and rodents. However, identifying the molecular bases of QTL remains a challenge. Here, we discuss why this is and how new experimental strategies and analytical techniques, combined with the fruits of the genome projects, are beginning to identify candidate genes for QTL studies in several model organisms.

摘要

了解数量遗传变异的分子基础是生物医学的一个主要目标。尽管数量性状复杂的遗传结构至今在很大程度上阻碍了通过标准连锁方法在人类中鉴定基因的尝试，但数量性状基因座（QTL）已在植物、昆虫和啮齿动物中被定位。然而，确定QTL的分子基础仍然是一项挑战。在此，我们讨论为何如此，以及新的实验策略和分析技术如何与基因组计划的成果相结合，开始在几种模式生物中鉴定用于QTL研究的候选基因。