转录记忆的机制。

Mechanisms of transcriptional memory.

作者信息

Francis N J, Kingston R E

机构信息

Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA.

出版信息

Nat Rev Mol Cell Biol. 2001 Jun;2(6):409-21. doi: 10.1038/35073039.

DOI:10.1038/35073039

PMID:11389465

Abstract

How can the same gene remember that it is 'off' in one cell lineage and 'on' in another? Studies of how homeotic genes are regulated in Drosophila melanogaster have uncovered a transcriptional maintenance system, encoded by the Polycomb and trithorax group genes, that preserves expression patterns across development. Here we try to formulate a broad framework for the types of molecular mechanism used by the Polycomb and trithorax proteins.

摘要

同一个基因如何记住它在一个细胞谱系中是“关闭”的，而在另一个细胞谱系中是“开启”的呢？对黑腹果蝇中同源异型基因调控方式的研究揭示了一种由多梳蛋白和三胸节蛋白家族基因编码的转录维持系统，该系统在整个发育过程中保持基因表达模式。在这里，我们试图为多梳蛋白和三胸节蛋白所使用的分子机制类型构建一个广泛的框架。