Ringrose Leonie, Paro Renato
ZMBH, University of Heidelberg, 69120 Heidelberg, Germany.
Annu Rev Genet. 2004;38:413-43. doi: 10.1146/annurev.genet.38.072902.091907.
During the development of multicellular organisms, cells become different from one another by changing their genetic program in response to transient stimuli. Long after the stimulus is gone, "cellular memory" mechanisms enable cells to remember their chosen fate over many cell divisions. The Polycomb and Trithorax groups of proteins, respectively, work to maintain repressed or active transcription states of developmentally important genes through many rounds of cell division. Here we review current ideas on the protein and DNA components of this transcriptional memory system and how they interact dynamically with each other to orchestrate cellular memory for several hundred genes.
在多细胞生物的发育过程中，细胞通过响应瞬时刺激改变其遗传程序而彼此变得不同。在刺激消失很久之后，“细胞记忆”机制使细胞能够在许多次细胞分裂中记住其选定的命运。多梳蛋白组和三胸蛋白组的蛋白质分别通过多轮细胞分裂维持发育重要基因的抑制或活跃转录状态。在这里，我们综述了关于这个转录记忆系统的蛋白质和DNA组成部分的当前观点，以及它们如何相互动态作用以协调数百个基因的细胞记忆。
