Src的搜寻。

The hunting of the Src.

作者信息

Martin G S

机构信息

Department of Molecular and Cell Biology, University of California, 401 Barker Hall #3204, Berkeley, California 94720-3204, USA.

出版信息

Nat Rev Mol Cell Biol. 2001 Jun;2(6):467-75. doi: 10.1038/35073094.

DOI:10.1038/35073094

PMID:11389470

Abstract

The non-receptor tyrosine kinase Src is important for many aspects of cell physiology. The viral src gene was the first retroviral oncogene to be identified, and its cellular counterpart was the first proto-oncogene to be discovered in the vertebrate genome. Src has been important, not only as an object of study in itself, but also as an entry point into the molecular genetics of cancer.

摘要

非受体酪氨酸激酶Src在细胞生理学的许多方面都很重要。病毒src基因是第一个被鉴定的逆转录病毒癌基因，其细胞对应物是在脊椎动物基因组中发现的第一个原癌基因。Src不仅本身作为一个研究对象很重要，而且作为癌症分子遗传学的一个切入点也很重要。