Toro L., Wallner M., Meera P., Tanaka Y.
Dept. of Anesthesiology at the University of California at Los Angeles School of Medicine, Los Angeles, CA 90095-1778, USA.
News Physiol Sci. 1998 Jun;13:112-117. doi: 10.1152/physiologyonline.1998.13.3.112.
Large-conductance, voltage-, and Ca(2+)-sensitive K(+) (maxi-K(Ca)) channels regulate neuronal and smooth muscle excitability. Their pore-forming alpha-subunit shows similarities with voltage-gated channels and indeed can open in the practical absence of Ca(2+). The NH(2) terminus is unique, with a seventh transmembrane segment involved in beta-subunit modulation. The long COOH terminus is implied in Ca(2+) modulation.
大电导、电压和钙敏感钾通道（大电导钙激活钾通道）调节神经元和平滑肌的兴奋性。它们的孔形成α亚基与电压门控通道有相似之处，实际上在几乎没有钙离子的情况下也能开放。氨基末端是独特的，其第七个跨膜片段参与β亚基调节。长羧基末端与钙调节有关。
