Senagore A J, Whalley D, Delaney C P, Mekhail N, Duepree H J, Fazio V W
Department of Colorectal Surgery, Cleveland Clinic Foundation, Cleveland, Ohio.
Surgery. 2001 Jun;129(6):672-6. doi: 10.1067/msy.2001.114648.
Aggressive postoperative care plans after open colectomy may allow earlier discharge, especially in conjunction with preoperative thoracic epidural anesthesia-analgesia using a local anesthetic and narcotic. The purpose of this study was to evaluate the role of thoracic epidural anesthesia-analgesia using bupivacaine and fentanyl citrate in reducing lengths of stay after laparoscopic colectomy (LAC).
A consecutive cohort of patients who underwent LAC and who received perioperative thoracic epidural anesthesia-analgesia (TEG) was compared with a standard group of patients (STD) undergoing LAC during the 2 months preceding the implementation of the epidural management protocol. Patients with TEG received 6 to 8 mL bupivacaine (0.25%) and fentanyl citrate (100 microg) through a T8-9 or a T9-10 epidural catheter before the incision was made and a postoperative infusion of bupivacaine (0.1%) and fentanyl citrate (5 microg/mL) at 4 to 6 mL/h for 18 hours. STD patients had supplemental intravenous morphine. The postoperative care plan was otherwise identical between the 2 groups. Patients were matched by sex, age, and type of segmental resection. Discharge criteria included tolerance of 3 general diet meals, passage of flatus or stool, and adequate oral analgesia. Length of stay was defined as the time from admission for the surgical procedure to discharge from the hospital. Statistical analysis included a Student t test, Wilcoxon rank sum test, chi-square trend test, and Fisher exact test where appropriate. Data are presented as mean +/- SEM.
Procedures performed were: right hemicolectomy-ileocolectomy (TEG, n = 5; STD, n = 5); or sigmoid colectomy-rectopexy (TEG, n = 17; STD, n = 17). There was no significant difference with respect to operating room (OR) time (TEG, 102 +/- 12 minutes; STD, 87 +/- 17 minutes), body mass index (TEG, 26 +/- 2; STD, 26 +/- 2), or American Society of Anesthesiologists class (I-III) distribution (TEG, 3/12/10; STD, 4/11/7), or mean incision length (TEG, 3.5 +/- 0.4 cm; STD, 3.7 +/- 0.3 cm.) No postoperative complications or readmissions occurred in either group. The length of stay decreased in the TEG group (TEG, 2.8 +/- 0.2 days; STD, 3.9 +/- 0.3; P <.001) and the median length of stay for the 2 groups was similarly less (TEG, 2 days; STD, 3 days).
These data suggest that thoracic epidural anesthesia-analgesia has a significant and favorable impact on dietary tolerance and length of stay after LAC. A thoracic epidural appears to be an important component of a postoperative care protocol, which adds further advantage to LAC without the need for labor-intensive and costly patient care plans.
开放性结肠切除术后积极的术后护理计划可能会使患者更早出院,尤其是在联合使用局部麻醉剂和麻醉性镇痛药进行术前胸段硬膜外麻醉镇痛的情况下。本研究的目的是评估使用布比卡因和枸橼酸芬太尼进行胸段硬膜外麻醉镇痛在缩短腹腔镜结肠切除术(LAC)后住院时间方面的作用。
将接受LAC并接受围手术期胸段硬膜外麻醉镇痛(TEG)的连续队列患者与在硬膜外管理方案实施前2个月内接受LAC的标准组患者(STD)进行比较。TEG组患者在切口前通过T8 - 9或T9 - 10硬膜外导管接受6至8毫升布比卡因(0.25%)和枸橼酸芬太尼(100微克),术后以4至6毫升/小时的速度输注布比卡因(0.1%)和枸橼酸芬太尼(5微克/毫升),持续18小时。STD组患者接受静脉补充吗啡。两组的术后护理计划在其他方面相同。患者按性别、年龄和节段性切除类型进行匹配。出院标准包括能耐受3顿普通饮食、有排气或排便以及充分的口服镇痛。住院时间定义为从手术入院到出院的时间。统计分析包括在适当情况下进行的学生t检验、威尔科克森秩和检验、卡方趋势检验和费舍尔精确检验。数据以平均值±标准误表示。
所进行的手术包括:右半结肠切除术 - 回结肠切除术(TEG组,n = 5;STD组,n = 5);或乙状结肠切除术 - 直肠固定术(TEG组,n = 17;STD组,n = 17)。在手术室(OR)时间(TEG组,102±12分钟;STD组,87±17分钟)、体重指数(TEG组,26±2;STD组,26±2)、美国麻醉医师协会分级(I - III级)分布(TEG组,3/12/10;STD组,4/11/7)或平均切口长度(TEG组,3.5±0.4厘米;STD组,3.7±0.3厘米)方面无显著差异。两组均未发生术后并发症或再次入院情况。TEG组的住院时间缩短(TEG组,2.8±0.2天;STD组,3.9±0.3天;P <.001),两组的住院时间中位数也同样缩短(TEG组,2天;STD组,3天)。
这些数据表明,胸段硬膜外麻醉镇痛对LAC后的饮食耐受性和住院时间有显著且有利的影响。胸段硬膜外麻醉似乎是术后护理方案的一个重要组成部分,它为LAC增添了进一步的优势,而无需劳动强度大且成本高的患者护理计划。