Guo Ding Y, Eteuati Jimmy, Nguyen M Hung, Lloyd David, Ragg Joe L
Department of Surgery, Launceston General Hospital, Launceston, Tasmania, Australia.
ANZ J Surg. 2007 Apr;77(4):283-6. doi: 10.1111/j.1445-2197.2007.04034.x.
This study presents an audit of the first 50 elective laparoscopic assisted colorectal resections carried out at the Launceston General Hospital, Tasmania, particularly in comparison with the 33 elective open resections carried out in the same 18-month period.
This was a retrospective review and analysis of prospectively recorded data on an intention-to-treat basis using non-parametric methods.
With respect to case selection, patients in the laparoscopic group were younger (median = 63 years (range 19-98 years) vs 69 years (33-93 years), P = 0.0392) and more patients had benign pathology (22/50, 44% vs 4/33, 12%, P = 0.002). There was no significant difference in sex or American Society of Anesthesiologists status (P = 0.499 and 0.517, respectively). There were more left-sided than right-sided resections (28/50, 56% vs 14/33, 42%, P = 0.118), along with more total colectomies in the laparoscopic group (7 vs 2). Operation times in the laparoscopic group were longer (197.5 min (87-452 min) vs 144 min (70-260 min), P = 0.0002) and no significant reduction was recorded over the study period (P = 0.50). There were five conversions from laparoscopic to open procedure (a 10% incidence). Compared with the open colectomy group, patients who underwent laparoscopic resections required less parenteral analgesia (2 days (1-5 days) vs 3 days (0-6 days), P < 0.0001). They had earlier first flatus (3 days (1-7 days) vs 4 days (1-6 days), P = 0.0069) and bowel movement (3 days (1-7 days) vs 4 days (2-9 days), P = 0.0021), tolerated solid diet earlier (3 days (1-9 days) vs 4 days (1-30 days), P = 0.0001) and had shorter hospital stay (5 days (3-12 days) vs 7 days (4-37 days), P = 0.0009). Less major perioperative complications were recorded for the laparoscopic group (2/50 vs 4/33, P = 0.162), but very little difference was found with respect to minor complications (17/50 vs 10/33, P = 0.725). For carcinoma resections, there were no positive resection margins. In the laparoscopic group, tumour size was smaller (3.25 cm (1-7 cm) vs 5 cm (2-15 cm), P = 0.0014) and less lymph nodes were harvested (6 (2-16) vs 8 (3-23), P = 0.101).
Laparoscopic colectomy allowed early postoperative recovery and shorter hospital stay. This was at the expense of a longer operation. It can be taken up by relatively laparoscopically naive surgeons without extra major morbidity/mortality associated with the learning curve. It is technically feasible and safe in small centres.
本研究对塔斯马尼亚朗塞斯顿综合医院开展的前50例择期腹腔镜辅助结直肠切除术进行了审计,特别是与同一18个月期间进行的33例择期开放切除术进行比较。
这是一项回顾性研究,对前瞻性记录的数据进行意向性分析,并采用非参数方法。
在病例选择方面,腹腔镜组患者更年轻(中位数=63岁(范围19 - 98岁)对69岁(33 - 93岁),P = 0.0392),且更多患者患有良性病变(22/50,44%对4/33,12%,P = 0.002)。性别或美国麻醉医师协会分级无显著差异(分别为P = 0.499和0.517)。左侧切除术多于右侧切除术(28/50,56%对14/33,42%,P = 0.118),腹腔镜组全结肠切除术也更多(7例对2例)。腹腔镜组手术时间更长(197.5分钟(87 - 452分钟)对144分钟(70 - 260分钟),P = 0.0002),且在研究期间未记录到显著缩短(P = 0.50)。有5例从腹腔镜手术转为开放手术(发生率为10%)。与开放结肠切除术组相比,接受腹腔镜切除术的患者需要的胃肠外镇痛更少(2天(1 - 5天)对3天(0 - 6天),P < 0.0001)。他们首次排气更早(3天(1 - 7天)对4天(1 - 6天),P = 0.0069)和排便更早(3天(1 - 7天)对4天(2 - 9天),P = 0.0021),更早耐受固体饮食(3天(1 - 9天)对4天(1 - 30天),P = 0.0001),住院时间更短(5天(3 - 12天)对7天(4 - 37天),P = 0.0009)。腹腔镜组记录的围手术期主要并发症较少(2/50对4/33,P = 0.162),但在轻微并发症方面差异很小(17/50对10/33,P = 0.725)。对于癌切除术,切缘均为阴性。在腹腔镜组中,肿瘤大小更小(3.25厘米(1 - 7厘米)对5厘米(2 - 15厘米),P = 0.0014),切除的淋巴结更少(6个(2 - 16个)对8个(3 - 23个),P = 0.101)。
腹腔镜结肠切除术可使患者术后早期恢复且住院时间缩短。这是以手术时间延长为代价的。相对缺乏腹腔镜经验的外科医生也可开展,且与学习曲线相关的额外严重发病率/死亡率较低。在小型中心,该手术在技术上是可行且安全的。