O'Driscoll P T, McGough J, Hagan H, Thiede H, Critchlow C, Alexander E R
Department of Epidemiology, School of Public Health and Community Medicine, University of Washington, Seattle, USA.
Am J Public Health. 2001 Jun;91(6):984-7. doi: 10.2105/ajph.91.6.984.
This study evaluated factors associated with accidental fatal drug overdose among a cohort of injection drug users (IDUs).
In a prospective cohort study of 2849 IDUs in King County, Washington, deaths were identified by electronically merging subject identifiers with death certificate records. Univariate and multivariate Cox regression analyses were performed to identify predictors of overdose mortality.
Thirty-two overdoses were observed. Independent predictors of overdose mortality were bisexual sexual orientation (relative risk [RR] = 4.86; 95% confidence interval [CI] = 2.30, 13.2), homelessness (RR = 2.30; 95% CI = 1.06, 5.01), infrequent injection of speedballs (RR = 5.36; 95% CI = 1.58, 18.1), daily use of powdered cocaine (RR = 4.84; 95% CI = 1.13, 20.8), and daily use of poppers (RR = 22.0; 95% CI = 1.74, 278).
Sexual orientation, homelessness, and drug use identify IDUs who may benefit from targeted interventions.
本研究评估了一组注射吸毒者(IDU)中与意外致命药物过量相关的因素。
在华盛顿州金县对2849名注射吸毒者进行的前瞻性队列研究中,通过将受试者标识符与死亡证明记录进行电子合并来确定死亡情况。进行单变量和多变量Cox回归分析以确定过量死亡率的预测因素。
观察到32例药物过量情况。过量死亡率的独立预测因素为双性恋性取向(相对风险[RR]=4.86;95%置信区间[CI]=2.30,13.2)、无家可归(RR=2.30;95%CI=1.06,5.01)、不常注射快克可卡因(RR=5.36;95%CI=1.58,18.1)、每日使用粉末状可卡因(RR=4.84;95%CI=1.13,20.8)以及每日使用Poppers(RR=22.0;95%CI=1.74,278)。
性取向、无家可归和吸毒情况可识别出可能从针对性干预中受益的注射吸毒者。