[吗啡给药继发急性疾病所致大疱性皮肤肥大细胞增多症]
[Bullous cutaneous mastocytosis revealed by acute disease secondary to morphine administration].
作者信息
Leblanc L, de Monléon J V, Faber V, Beer F, Dalac S, Justrabo E, Lambert D, Huet F
机构信息
Service de dermatologie, centre hospitalier universitaire de Dijon, 10, boulevard du Maréchal-de-Lattre-de-Tassigny, 21034 Dijon, France.
出版信息
Arch Pediatr. 2001 May;8(5):512-5. doi: 10.1016/s0929-693x(00)00255-4.
UNLABELLED
Mastocytosis in children shows in three clinical forms. The rarest is the diffuse or bullous form.
CASE REPORT
Since one month of age an infant showed a diffuse erythema and vesicle rash. At four months of age, serious discomfort after morphinic absorption led to the diagnosis of bullous cutaneous mastocytosis. Histologic examination confirmed this diagnosis. The clinical severity led to intravenous corticosteroid and antihistamine therapy.
COMMENTS
Bullous cutaneous mastocytosis is unusual in children. However, it should be considered if there are any doubts because of its serious complications and iatrogenic therapeutic risks. Some serious cases require intravenous corticosteroid therapy. Appropriate care enables a normal development with a disappearance of the disease before the teenage years.
未标注
儿童肥大细胞增多症有三种临床形式。最罕见的是弥漫性或大疱性形式。
病例报告
一名婴儿自1月龄起出现弥漫性红斑和水疱性皮疹。4月龄时，吗啡吸收后出现严重不适，诊断为大疱性皮肤肥大细胞增多症。组织学检查证实了这一诊断。临床严重程度导致采用静脉注射皮质类固醇和抗组胺药治疗。
评论
大疱性皮肤肥大细胞增多症在儿童中并不常见。然而，由于其严重并发症和医源性治疗风险，如果有任何疑问都应予以考虑。一些严重病例需要静脉注射皮质类固醇治疗。适当的护理可使疾病在青少年期前消失并实现正常发育。
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