Lee J K, Tsai S C, Ho Y J, Changlai S P, Kao C H
Department of Nuclear Medicine, China Medical College Hospital, Taichung, Taiwan.
Anticancer Res. 2001 Mar-Apr;21(2B):1509-13.
The aim of this study was to assess the use of Tc-99m tetrofosmin (Tc-TF) scintigraphy for detecting malignant lymphomas. In the study, before any chemotherapy, 50 patients with malignant lymphoma underwent Tc-TF scintigraphy, which was performed 10 minutes after intravenous injection of 20 mCt Tc-TF. Tc-TF scintigraphy detected malignant lymphoma in 44 (88%) patients. However, there were no significant differences in the incidences of positive and negative Tc-TF scintigraphic results between female versus male patients, HD versus NHL patients, stage I-II versus stage III-IV patients, age > 40 years versus < or = 40 years patients and patients with B symptoms false-negative results occurred in 4 (8%) infradiaphragmatic malignant lymphoma. We conclude patients with that Tc-TF scintigraphy appears suitable for detecting malignant lymphoma, especially supradiaphragmatic lesions.
本研究的目的是评估锝-99m替曲膦（Tc-TF）闪烁显像在检测恶性淋巴瘤中的应用。在该研究中，50例恶性淋巴瘤患者在进行任何化疗之前接受了Tc-TF闪烁显像检查，于静脉注射20 mCi Tc-TF后10分钟进行。Tc-TF闪烁显像在44例（88%）患者中检测到恶性淋巴瘤。然而，女性与男性患者、霍奇金淋巴瘤（HD）与非霍奇金淋巴瘤（NHL）患者、Ⅰ-Ⅱ期与Ⅲ-Ⅳ期患者、年龄＞40岁与≤40岁患者之间，Tc-TF闪烁显像阳性和阴性结果的发生率无显著差异；4例（8%）膈下恶性淋巴瘤患者出现假阴性结果。我们得出结论，Tc-TF闪烁显像似乎适用于检测恶性淋巴瘤，尤其是膈上病变。
