Delzenne N M, Verbeeck R K
Unité de Pharmacocinétique, Métabolisme, Nutrition et Toxicologie, Ecole de Pharmacie Université Catholique de Louvain MD/FARM/PMNT 7369, Avenue Emmanuel Mounier, 73 B-1200 Bruxelles.
J Pharm Belg. 2001 Mar-Apr;56(2):33-7.
The nutritional state, and/or the ingestion of specific nutrients, is/are able to modify drug disposition, by interfering with drug absorption, distribution, storage, and metabolism. Recent data report that nutrients interfere with drug metabolism either by modifying key enzymes of phase I (cytochromeP450 dependent mixed function oxidase) and II (glucuronosyl, sulfonyl- ... transferases), or by modulating coenzymes availability (NADPH, UDPglucuronic acid...). Food components involved in drug metabolism modifications are either macro-nutrients (carbohydrates, lipids, proteins, ethanol), micronutriments (vitamins, minerals), or phytochemicals. Drug-nutrients interactions may be beneficials, and thus could constitute, i.e. a way to improve drug therapeutic index, or generate adverse effects.
营养状况和/或特定营养素的摄入能够通过干扰药物的吸收、分布、储存和代谢来改变药物的处置。最近的数据表明，营养素通过改变I相（细胞色素P450依赖性混合功能氧化酶）和II相（葡糖醛酸基、磺酰基……转移酶）的关键酶，或通过调节辅酶的可用性（NADPH、UDP葡糖醛酸……）来干扰药物代谢。参与药物代谢改变的食物成分包括宏量营养素（碳水化合物、脂质、蛋白质、乙醇）、微量营养素（维生素、矿物质）或植物化学物质。药物与营养素的相互作用可能是有益的，因此可能构成一种提高药物治疗指数的方法，也可能产生不良反应。
