使用可控微波加热的快速均相Sonogashira偶联反应
Rapid homogeneous-phase Sonogashira coupling reactions using controlled microwave heating.
作者信息
Erdélyi M, Gogoll A
机构信息
Department of Organic Chemistry, Uppsala University, Box 531, 751 21 Uppsala, Sweden.
出版信息
J Org Chem. 2001 Jun 15;66(12):4165-9. doi: 10.1021/jo0057250.
PMID:11397149
Abstract
A microwave-enhanced, rapid and efficient homogeneous-phase version of the Sonogashira reaction is presented. It has been applied to the coupling of aryl iodides, bromides, triflates, and aryl chloride, as well as pyridine and thiophene derivatives with trimethylsilylacetylene. Excellent yields (80-95%) for substrates containing a large variety of substituents in different positions are obtained in 5-25 min.
摘要
本文介绍了一种微波增强的、快速高效的Sonogashira反应均相版本。它已应用于芳基碘化物、溴化物、三氟甲磺酸酯、芳基氯以及吡啶和噻吩衍生物与三甲基硅基乙炔的偶联反应。在5至25分钟内，对于在不同位置含有多种取代基的底物可获得优异的产率（80 - 95%）。
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