Williams M.M., Spiess B.M., Pascoe P.J., O'Grady M.
Toronto Yorke, Veterinary Ophthalmologists, 14834 Yonge Street, Aurora, Ontario L4G 1N2, Canada; Department of Veterinary Surgery, University of Zurich, Winterthurerstrasse 260, CH-8057 Zurich, Switzerland; Department of Surgical & Radiological Sciences, School of Veterinary Medicine, University of California, Davis, California 95616-8742, USA; Department of Clinical Studies, Ontario Veterinary College, University of Guelph, Guelph, Ontario N1G 2W1, Canada.
Vet Ophthalmol. 2000;3(2-3):193-199. doi: 10.1046/j.1463-5224.2000.00118.x.
To identify any systemic effects of topical and subconjunctival administration of atropine sulfate in the horse. Animals studied Six mature grade horses were treated hourly in one eye with topical ophthalmic atropine drops for 24 h. Five horses were treated subconjunctivally in one eye with 3 mg of atropine sulfate. Procedures Pupillary light reflexes, pupil size, electrocardiographic parameters, girth measurements, intestinal motility, and clinical signs of abdominal pain were monitored. RESULTS: Alteration in auscultated gut motility and clinical signs of abdominal pain were the most sensitive indicators of the systemic manifestations of the topically applied atropine. Gut motility was absent in all horses for periods of 2-18 h in all four abdominal quadrants in horses given topically administered atropine. Signs of abdominal pain were observed in four of six horses that received topical atropine. In the subconjunctival test study, gut motility was absent in three horses for periods of 3-7 h. Uniocular subconjunctival injection of 3 mg atropine sulfate produced signs of abdominal pain in one of six horses. Conclusion The ophthalmic administration of atropine can affect gut motility and induce signs of colic in selected horses.
确定硫酸阿托品局部和结膜下给药对马的全身影响。研究动物 六匹成年杂种马，一只眼睛每小时用眼科局部阿托品滴眼液治疗24小时。五匹马一只眼睛结膜下注射3毫克硫酸阿托品。程序 监测瞳孔对光反射、瞳孔大小、心电图参数、腹围测量、肠道蠕动以及腹痛的临床体征。结果：听诊到的肠道蠕动改变和腹痛的临床体征是局部应用阿托品全身表现的最敏感指标。局部应用阿托品的马匹，所有四个腹部象限的肠道蠕动在2 - 18小时内均消失。接受局部阿托品治疗的六匹马中有四匹出现腹痛体征。在结膜下试验研究中，三匹马的肠道蠕动在3 - 7小时内消失。单眼结膜下注射3毫克硫酸阿托品使六匹马中的一匹出现腹痛体征。结论 阿托品的眼部给药可影响肠道蠕动并在部分马匹中诱发绞痛体征。
