Herring I.P., Pickett J.P., Champagne E.S., Troy G.C., Marini M.
Department of Small Animal Clinical Sciences, Virginia-Maryland Regional College of Veterinary Medicine, Virginia Tech, Blacksburg, VA 24061-0442, USA; Department of Small Animal Clinical Sciences, Virginia-Maryland Regional College of Veterinary Medicine, Virginia Tech, Blacksburg, VA 24061-0442, USA. Present address: College of Veterinary Medicine, University of Missouri, Columbia, MO 65211, USA; Department of Statistics, Virginia Tech, Blacksburg, VA 24061, USA.
Vet Ophthalmol. 2000;3(2-3):139-143. doi: 10.1046/j.1463-5224.2000.00134.x.
To determine the effect of topical 1% ophthalmic atropine sulfate on intraocular pressure (IOP) in ocular normotensive horses. Animals Studied Eleven clinically healthy horses. Procedures IOP was measured bilaterally twice daily, at 8 AM and 4 PM, for 5 days. No medication was applied for the first 2 days of the study. Thereafter, one eye of each horse was treated with 0.1 mL of topical 1% atropine sulfate ointment twice daily (7 AM and 7 PM) for 3 days. The contralateral eye served as a control. In eight of the horses, an additional IOP reading was taken 3 days following cessation of the atropine treatment. RESULTS: There was no significant difference in the IOP of control vs. treatment eyes in the pretreatment period, days 1 and 2 (P = 0.97 and 0.55, respectively). During the treatment period, treated eyes of 10 of the horses had significantly lower IOP than control eyes (P = 0.03). The mean IOP reduction in treated eyes, relative to untreated eyes, was 11.2%. One horse had a significant rise in IOP in the treated eye compared to the remaining study animals. The IOP of control eyes did not vary significantly over the observation period (P = 0.27). There was no significant variation in IOP between the 8 AM and 4 PM measurement (P = 0.9). CONCLUSIONS: Topical 1% atropine sulfate causes a small, but significant decline in IOP in most ocular normotensive horses. Because topical atropine may elevate IOP in some horses, it should be used with caution in the treatment of glaucoma in this species.
确定局部应用1%硫酸阿托品眼膏对眼压正常马匹眼压（IOP）的影响。
11匹临床健康的马。
在5天内，每天上午8点和下午4点对双侧眼压进行测量，共测量两次。在研究的前两天不使用任何药物。此后，每匹马的一只眼睛每天两次（上午7点和晚上7点）使用0.1 mL局部1%硫酸阿托品眼膏，持续3天。对侧眼睛作为对照。在8匹马中，在阿托品治疗停止3天后进行了额外的眼压读数测量。
在预处理期的第1天和第2天，对照眼和治疗眼的眼压无显著差异（P分别为0.97和0.55）。在治疗期间，10匹马的治疗眼眼压显著低于对照眼（P = 0.03）。与未治疗眼相比，治疗眼的平均眼压降低了11.2%。与其余研究动物相比，一匹马的治疗眼眼压显著升高。在观察期内，对照眼的眼压没有显著变化（P = 0.27）。上午8点和下午4点测量的眼压之间没有显著差异（P = 0.9）。
局部应用1%硫酸阿托品可使大多数眼压正常的马匹眼压有小幅但显著的下降。由于局部应用阿托品可能会使一些马匹的眼压升高，因此在该物种青光眼治疗中应谨慎使用。
