Pogátsa G, Bihari-Varga M, Szinay G
Acta Diabetol Lat. 1979 Apr-Jun;16(2):129-38. doi: 10.1007/BF02581092.
The effects of chronic antidiabetic treatment were examined in a clinically manifest, but non-ketotic diabetic animal model in which increased stabilization of steric structure in the cardiac connective tissue and left ventricular diastolic stiffness have been demonstrated. These changes accounted for decreased left ventricular performance during left ventricular afterload. Each of 8 diabetic dogs was given daily 8-16 IU of insulin, 250-750 mg carbutamide or 2-10 mg glibenclamide, respectively; doses were always adjusted to the actual metabolic requirements and findings were compared to those of 11 untreated diabetic and 6 healthy dogs. After three months, the hemodynamic and metabolic studies showed that the metabolically controlled diabetic dogs had less marked alterations in the connective cardiac tissue, left ventricular diastolic stiffness and performance. Apart from a considerable rise of arterial blood pressure during carbutamide treatment, no other difference was found in the cardiac actions of the three hypoglycemic agents tested.
在一个临床表现为糖尿病但无酮症的动物模型中，研究了慢性抗糖尿病治疗的效果。在该模型中，已证实心脏结缔组织的空间结构稳定性增加以及左心室舒张硬度增加。这些变化导致左心室后负荷期间左心室功能下降。8只糖尿病犬分别每日给予8 - 16 IU胰岛素、250 - 750 mg卡比马嗪或2 - 10 mg格列本脲；剂量始终根据实际代谢需求进行调整，并将结果与11只未治疗的糖尿病犬和6只健康犬的结果进行比较。三个月后，血流动力学和代谢研究表明，代谢得到控制的糖尿病犬在心脏结缔组织、左心室舒张硬度和功能方面的改变不那么明显。除了卡比马嗪治疗期间动脉血压显著升高外，在所测试的三种降糖药物的心脏作用方面未发现其他差异。
