dei Cas L, Zuliani U, Manca C, Zonca A, Bernardini B, Mansour M, Barilli A L
Acta Diabetol Lat. 1980 Apr-Jun;17(2):145-52. doi: 10.1007/BF02580996.
The authors studied the modification of systolic time intervals (STI), pre-ejection period (PEP) and left ventricular ejection time (LVETc), before and after isometric exercise, in 294 diabetic patients without clinical evidence of cardiomyopathy and in good metabolic control compared to 132 normal subjects. The study was aimed at detecting preclinical alterations of left ventricular function. Diabetic patients considered together did not show any difference in STI in basal conditions or after isometric exercise compared to normal subjects. When diabetic patients were divided into sub-groups according to their treatment, the insulin-treated diabetics showed modification of STI after isometric exercise, which indicated an alteration of left ventricular function. Also subjects treated with oral hypoglycemic agents showed similar but less evident changes. In diabetic patients on diet only and in those with duration of diabetes of 6 months or less, STI was identical to that of normal subjects. These data do not explain the pathogenesis of myocardial involvement, although they are in accordance with studies which have laid emphasis on the alteration of compliance of the diabetic heart.
作者对294例无心肌病临床证据且代谢控制良好的糖尿病患者以及132例正常受试者进行了研究，观察等长运动前后收缩期时间间期（STI）、射血前期（PEP）和左心室射血时间（LVETc）的变化。该研究旨在检测左心室功能的临床前改变。总体来看，糖尿病患者在基础状态或等长运动后，与正常受试者相比，STI没有任何差异。当根据治疗方法将糖尿病患者分为亚组时，胰岛素治疗的糖尿病患者在等长运动后STI发生改变，这表明左心室功能发生了改变。接受口服降糖药治疗的受试者也表现出类似但不太明显的变化。仅接受饮食治疗的糖尿病患者以及糖尿病病程在6个月或更短的患者，其STI与正常受试者相同。这些数据虽然与强调糖尿病心脏顺应性改变的研究一致，但并未解释心肌受累的发病机制。
