Cizza G, Ravn P, Chrousos G P, Gold P W
Clinical Neuroendocrinology Branch, NIMH, Bethesda, MD, USA.
Trends Endocrinol Metab. 2001 Jul;12(5):198-203. doi: 10.1016/s1043-2760(01)00407-6.
Existing studies of the relationship between depression and osteoporosis have been heterogeneous in their design and use of diagnostic instruments for depression, which might have contributed to the different results on the comorbidity of these two conditions. Nevertheless, these studies reveal a strong association between depression and osteoporosis. Endocrine factors such as depression-induced hypersecretion of corticotropin-releasing hormone and hypercortisolism, hypogonadism, growth hormone deficiency and increased concentration of circulating interleukin 6, might play a crucial role in the bone loss observed in subjects suffering from major depression.
现有关于抑郁症与骨质疏松症之间关系的研究在设计以及抑郁症诊断工具的使用方面存在差异，这可能导致了这两种病症共病情况的研究结果各异。然而，这些研究揭示了抑郁症与骨质疏松症之间存在紧密关联。诸如抑郁症导致促肾上腺皮质激素释放激素分泌过多和皮质醇增多症、性腺功能减退、生长激素缺乏以及循环白细胞介素6浓度升高之类的内分泌因素，可能在重度抑郁症患者出现的骨质流失中起着关键作用。
