Cizza Giovanni, Primma Svetlana, Csako Gyorgy
Clinical Endocrine Section, Clinical Endocrinology Branch, NIDDK, NIH, DHHS, USA.
Trends Endocrinol Metab. 2009 Oct;20(8):367-73. doi: 10.1016/j.tem.2009.05.003. Epub 2009 Sep 9.
Osteoporosis is a major public health threat. Multiple studies have reported an association between depression and low bone mineral density, but a causal link between these two conditions is disputed. Here we review the endocrine and immune alterations secondary to depression that might affect bone mass. We also discuss the possible role of poor lifestyle in the etiology of osteoporosis in subjects with depression and the potential effect of antidepressants on bone loss. We propose that depression induces bone loss and osteoporotic fractures, primarily via specific immune and endocrine mechanisms, while poor lifestyle habits and use of specific antidepressants are potential contributory factors.
骨质疏松症是对公众健康的重大威胁。多项研究报告了抑郁症与低骨密度之间的关联，但这两种情况之间的因果关系存在争议。在此，我们综述了抑郁症继发的可能影响骨量的内分泌和免疫改变。我们还讨论了不良生活方式在抑郁症患者骨质疏松症病因中的可能作用以及抗抑郁药对骨质流失的潜在影响。我们提出，抑郁症主要通过特定的免疫和内分泌机制导致骨质流失和骨质疏松性骨折，而不良生活习惯和特定抗抑郁药的使用是潜在的促成因素。
