Biassoni R, Cantoni C, Falco M, Pende D, Millo R, Moretta L, Bottino C, Moretta A
Istituto Nazionale per la Ricerca sul Cancro, Laboratorio di Immunologia, IST/CBA, L.go R. Benzi, 10, 16132, Genova, Italy.
Mol Immunol. 2000 Dec;37(17):1015-24. doi: 10.1016/s0161-5890(01)00018-9.
Natural killer (NK) cells were poorly characterized until 10 years ago and few molecules expressed on their cell surface were known. Now the situation has changed dramatically, since a plethora of receptors characterized by opposite functions have been functionally and molecularly defined. NK cells express clonally distributed inhibitory receptors specific for different groups of HLA class I alleles, thus protecting normal cells from NK-mediated lysis. On the contrary, various activating receptors are involved in triggering of NK-mediated natural cytotoxicity. Their engagement induces human NK cells to kill target cells that are either HLA class I-negative or -deficient. Here a brief description of the activating receptors and coreceptor and of their ligand(s) is given.
直到10年前，自然杀伤（NK）细胞的特征还鲜为人知，其细胞表面表达的分子也寥寥无几。如今，情况发生了巨大变化，因为大量具有相反功能的受体已在功能和分子层面得到明确界定。NK细胞表达针对不同组HLA I类等位基因的克隆性分布抑制性受体，从而保护正常细胞免受NK介导的裂解。相反，多种激活受体参与触发NK介导的自然细胞毒性。它们的结合会诱导人类NK细胞杀伤HLA I类阴性或缺陷的靶细胞。在此简要介绍一下激活受体、共受体及其配体。
