Fulton-Kehoe D, Hamman R F, Baxter J, Marshall J
Department of Environmental Health, School of Public Health and Community Medicine, University of Washington, Seattle, WA 80262, USA.
Ann Epidemiol. 2001 Jul;11(5):320-7. doi: 10.1016/s1047-2797(01)00218-6.
The purpose of this study was to examine the association between physical activity and non-insulin dependent diabetes mellitus (NIDDM).
We conducted a population-based case-control study in Hispanic and non-Hispanic white men and women, ages 20-74. A total of 167 cases with NIDDM and 1100 controls with normal glucose tolerance were included. All subjects completed an oral glucose tolerance test.
Persons with recently diagnosed NIDDM reported significantly lower levels of physical activity than control subjects. For total metabolic units, the odds ratio for subjects in the highest tertile compared to those in the lowest tertile was 0.60 (95% confidence interval (CI) = 0.37-0.98) after adjusting for age, sex, ethnicity, and family history of diabetes. The adjusted odds ratio for persons reporting high levels of vigorous activity (at least three times per week for 20 minutes) was also less than 1, but was not statistically significant (odds ratio (OR) = 0.73, 95% CI = 0.47-1.14). Similar adjusted odds ratios were observed for high versus low levels of self-assessed work activity (OR = 0.50, 95% CI = 0.34-0.74) and leisure time physical activity (OR = 0.62, 95% CI = 0.44-0.90). Further adjustments for body mass index attenuated the strength of the association between physical activity and NIDDM. This is consistent with the hypothesis that obesity is one consequence of physical inactivity that puts individuals at increased risk for NIDDM. The association of physical activity and NIDDM was stronger in Hispanic than in non-Hispanic white subjects, although this difference was not statistically significant.
High levels of physical activity are associated with lower odds of NIDDM and this relationship may be stronger in Hispanic subjects.
本研究旨在探讨体力活动与非胰岛素依赖型糖尿病（NIDDM）之间的关联。
我们在年龄为20 - 74岁的西班牙裔和非西班牙裔白人男性及女性中开展了一项基于人群的病例对照研究。共纳入167例NIDDM患者和1100例糖耐量正常的对照者。所有受试者均完成了口服葡萄糖耐量试验。
新诊断为NIDDM的患者报告的体力活动水平显著低于对照者。对于总代谢单位，在调整年龄、性别、种族和糖尿病家族史后，处于最高三分位数的受试者与最低三分位数的受试者相比，优势比为0.60（95%置信区间（CI）= 0.37 - 0.98）。报告高水平剧烈活动（每周至少三次，每次20分钟）的人的调整后优势比也小于1，但无统计学意义（优势比（OR）= 0.73，95% CI = 0.47 - 1.14）。在自我评估的工作活动高低水平（OR = 0.50，95% CI = 0.34 - 0.74）和休闲时间体力活动（OR = 0.62，95% CI = 0.44 - 0.90）方面也观察到类似的调整后优势比。对体重指数进行进一步调整后，体力活动与NIDDM之间关联的强度减弱。这与肥胖是体力活动不足的一个后果，使个体患NIDDM风险增加的假设一致。体力活动与NIDDM的关联在西班牙裔受试者中比在非西班牙裔白人受试者中更强，尽管这种差异无统计学意义。
高水平的体力活动与较低的NIDDM患病几率相关，且这种关系在西班牙裔受试者中可能更强。
